Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/153585
Title: Pharyngeal microbial signatures are predictive of the risk of fungal pneumonia in hematologic patients
Authors: Costantini, Claudio
Nunzi, Emilia
Spolzino, Angelica
Palmieri, Melissa
Renga, Giorgia
Zelante, Teresa
Englmaier, Lukas
Coufalikova, Katerina
Spáčil, Zdeněk
Borghi, Monica
Bellet, Marina M.
Acerbi, Enzo
Puccetti, Matteo
Giovagnoli, Stefano
Spaccapelo, Roberta
Talesa, Vincenzo N.
Lomurno, Giuseppe
Merli, Francesco
Facchini, Luca
Spadea, Antonio
Melillo, Lorella
Codeluppi, Katia
Marchesi, Francesco
Marchesini, Gessica
Valente, Daniela
Dragonetti, Giulia
Nadali, Gianpaolo
Pagano, Livio
Aversa, Franco
Romani, Luigina
Keywords: Science::Biological sciences
Issue Date: 2021
Source: Costantini, C., Nunzi, E., Spolzino, A., Palmieri, M., Renga, G., Zelante, T., Englmaier, L., Coufalikova, K., Spáčil, Z., Borghi, M., Bellet, M. M., Acerbi, E., Puccetti, M., Giovagnoli, S., Spaccapelo, R., Talesa, V. N., Lomurno, G., Merli, F., Facchini, L., ...Romani, L. (2021). Pharyngeal microbial signatures are predictive of the risk of fungal pneumonia in hematologic patients. Infection and Immunity, 89(8), e0010521-21-. https://dx.doi.org/10.1128/IAI.00105-21
Journal: Infection and Immunity
Abstract: The ability to predict invasive fungal infections (IFI) in patients with hematological malignancies is fundamental for successful therapy. Although gut dysbiosis is known to occur in hematological patients, whether airway dysbiosis also contributes to the risk of IFI has not been investigated. Nasal and oropharyngeal swabs were collected for functional microbiota characterization in 173 patients with hematological malignancies recruited in a multicenter, prospective, observational study and stratified according to the risk of developing IFI. A lower microbial richness and evenness were found in the pharyngeal microbiota of high-risk patients that were associated with a distinct taxonomic and metabolic profile. A murine model of IFI provided biologic plausibility for the finding that loss of protective anaerobes, such as Clostridiales and Bacteroidetes, along with an apparent restricted availability of tryptophan, is causally linked to the risk of IFI in hematologic patients and indicates avenues for antimicrobial stewardship and metabolic reequilibrium in IFI.
URI: https://hdl.handle.net/10356/153585
ISSN: 0019-9567
DOI: 10.1128/IAI.00105-21
Rights: © 2021 American Society for Microbiology. All Rights Reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCELSE Journal Articles

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