Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/153615
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dc.contributor.authorChen, Yuqingen_US
dc.contributor.authorKassam, Irfahanen_US
dc.contributor.authorLau, Suk Hiangen_US
dc.contributor.authorKooner, Jaspal S.en_US
dc.contributor.authorWilson, Roryen_US
dc.contributor.authorPeters, Annetteen_US
dc.contributor.authorWinkelmann, Julianeen_US
dc.contributor.authorChambers, John C.en_US
dc.contributor.authorChow, Vincent T.en_US
dc.contributor.authorKhor, Chiea Chuenen_US
dc.contributor.authorVan Dam, Rob M.en_US
dc.contributor.authorTeo, Yik-Yingen_US
dc.contributor.authorLoh, Marieen_US
dc.contributor.authorSim, Xuelingen_US
dc.date.accessioned2021-12-14T07:59:20Z-
dc.date.available2021-12-14T07:59:20Z-
dc.date.issued2021-
dc.identifier.citationChen, Y., Kassam, I., Lau, S. H., Kooner, J. S., Wilson, R., Peters, A., Winkelmann, J., Chambers, J. C., Chow, V. T., Khor, C. C., Van Dam, R. M., Teo, Y., Loh, M. & Sim, X. (2021). Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood : an EWAS in multi-ethnic Asian individuals. Clinical Epigenetics, 13(1), 195-. https://dx.doi.org/10.1186/s13148-021-01162-xen_US
dc.identifier.issn1868-7075en_US
dc.identifier.urihttps://hdl.handle.net/10356/153615-
dc.description.abstractThe prevalence of obesity and its related chronic diseases have been increasing especially in Asian countries. Obesity-related genetic variants have been identified, but these explain little of the variation in BMI. Recent studies reported associations between DNA methylation and obesity, mostly in non-Asian populations.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.description.sponsorshipMinistry of Health (MOH)en_US
dc.description.sponsorshipNational Medical Research Council (NMRC)en_US
dc.description.sponsorshipNational Research Foundation (NRF)en_US
dc.language.isoenen_US
dc.relationNMRC/OFYIRG/038/2017-00en_US
dc.relation03/1/27/18/216en_US
dc.relation0838/2004en_US
dc.relation05/1/21/19/425en_US
dc.relation11/1/21/19/678en_US
dc.relation.ispartofClinical Epigeneticsen_US
dc.rights© 2021 The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.en_US
dc.subjectScience::Medicineen_US
dc.titleImpact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood : an EWAS in multi-ethnic Asian individualsen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.identifier.doi10.1186/s13148-021-01162-x-
dc.description.versionPublished versionen_US
dc.identifier.pmid34670603-
dc.identifier.scopus2-s2.0-85117604039-
dc.identifier.issue1en_US
dc.identifier.volume13en_US
dc.identifier.spage195en_US
dc.subject.keywordsDNA Methylationen_US
dc.subject.keywordsEpigenome-Wide Association Studyen_US
dc.description.acknowledgementThis research is supported by the Singapore Ministry of Health’s National Medical Research Council (NMRC/OFYIRG/038/2017-00). The iOmics study is supported by the Biomedical Research Council (grant 03/1/27/18/216), National Medical Research Council (grant 0838/2004) and National Research Foundation (through the Bio-medical Research Council, grants 05/1/21/19/425 and 11/1/21/19/678), and is partly supported by funds from the Agency for Science, Technology and Research (A∗STAR) and the National University of Singapore (NUS) [Translational Laboratory in Genetic Medicine— Integrative Omics Group (TLGM-iOX)]. The contributions from the KORA study were supported by a grant (01EA1902A: Dimension) from the German Federal Ministry of Education and Research (BMBF) within the framework of the EU Joint Programming Initiative ‘A Healthy Diet for a Healthy Life’.en_US
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