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https://hdl.handle.net/10356/153678| Title: | The Qcrb inhibitors TB47 and telacebec do not potentiate the activity of clofazimine in mycobacterium abscessus | Authors: | Sorayah, Ria Moraski, Garret C. Barkan, Daniel Pethe, Kevin |
Keywords: | Medicine, Health and Life Sciences | Issue Date: | 2021 | Source: | Sorayah, R., Moraski, G. C., Barkan, D. & Pethe, K. (2021). The Qcrb inhibitors TB47 and telacebec do not potentiate the activity of clofazimine in mycobacterium abscessus. Antimicrobial Agents and Chemotherapy, 65(12), e0096421-. https://dx.doi.org/10.1128/AAC.00964-21 | Project: | NRF-NRFI06-2020-0004 | Journal: | Antimicrobial Agents and Chemotherapy | Abstract: | The antituberculosis drug telacebec is ineffective against Mycobacterium abscessus. A recent study suggested that TB47, a telacebec analogue, potentiated the efficacy of clofazimine against M. abscessus. Here, we report that TB47 not only is ineffective against M. abscessus in vitro but also does not potentiate the activity of clofazimine. | URI: | https://hdl.handle.net/10356/153678 | ISSN: | 0066-4804 | DOI: | 10.1128/AAC.00964-21 | Schools: | Lee Kong Chian School of Medicine (LKCMedicine) School of Biological Sciences Interdisciplinary Graduate School (IGS) |
Rights: | © 2021 American Society for Microbiology. All Rights Reserved. This article may be downloaded for personal use only. Any other use requires prior permission of the copyright holder. The Version of Record is available online at http://doi.org/10.1128/AAC.00964-21. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
| Appears in Collections: | LKCMedicine Journal Articles SBS Journal Articles |
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| The QcrB Inhibitors TB47 and Telacebec Do Not Potentiate the Activity of Clofazimine in Mycobacterium abscessus_submitted.pdf | 155.94 kB | Adobe PDF |  View/Open |
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