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Title: Induction of native c-di-GMP phosphodiesterases leads to dispersal of pseudomonas aeruginosa biofilms
Authors: Andersen, Jens Bo
Kragh, Kasper Nørskov
Hultqvist, Louise Dahl
Rybtke, Morten
Nilsson, Martin
Jakobsen, Tim Holm
Givskov, Michael
Tolker-Nielsen, Tim
Keywords: Engineering::Environmental engineering
Issue Date: 2021
Source: Andersen, J. B., Kragh, K. N., Hultqvist, L. D., Rybtke, M., Nilsson, M., Jakobsen, T. H., Givskov, M. & Tolker-Nielsen, T. (2021). Induction of native c-di-GMP phosphodiesterases leads to dispersal of pseudomonas aeruginosa biofilms. Antimicrobial Agents and Chemotherapy, 65(4), e02431-20-.
Journal: Antimicrobial Agents and Chemotherapy
Abstract: A decade of research has shown that the molecule c-di-GMP functions as a central second messenger in many bacteria. A high level of c-di-GMP is associated with biofilm formation, whereas a low level of c-di-GMP is associated with a planktonic single-cell bacterial lifestyle. c-di-GMP is formed by diguanylate cyclases and is degraded by specific phosphodiesterases. We previously presented evidence that the ectopic expression of the Escherichia coli phosphodiesterase YhjH in Pseudomonas aeruginosa results in biofilm dispersal. More recently, however, evidence has been presented that the induction of native c-di-GMP phosphodiesterases does not lead to a dispersal of P. aeruginosa biofilms. The latter result may discourage attempts to use c-di-GMP signaling as a target for the development of antibiofilm drugs. However, here, we demonstrate that the induction of the P. aeruginosa c-di-GMP phosphodiesterases PA2133 and BifA indeed results in the dispersal of P. aeruginosa biofilms in both a microtiter tray biofilm assay and a flow cell biofilm system.
ISSN: 0066-4804
DOI: 10.1128/AAC.02431-20
Rights: © 2021 American Society for Microbiology. All Rights Reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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