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Title: Genomic profiling of mycobacterium tuberculosis strains, Myanmar
Authors: Aung, Htin Lin
Nyunt, Wint Wint
Fong, Yang
Biggs, Patrick J.
Winkworth, Richard C.
Lockhart, Peter J.
Yeo, Tsin Wen
Hill, Philip C.
Cook, Gregory M.
Aung, Si Thu
Keywords: Science::Medicine
Issue Date: 2021
Source: Aung, H. L., Nyunt, W. W., Fong, Y., Biggs, P. J., Winkworth, R. C., Lockhart, P. J., Yeo, T. W., Hill, P. C., Cook, G. M. & Aung, S. T. (2021). Genomic profiling of mycobacterium tuberculosis strains, Myanmar. Emerging Infectious Diseases, 27(11), 2847-2855.
Journal: Emerging Infectious Diseases 
Abstract: Multidrug resistance is a major threat to global elimination of tuberculosis (TB). We performed phenotypic drug-susceptibility testing and whole-genome sequencing for 309 isolates from 342 consecutive patients who were given a diagnosis of TB in Yangon, Myanmar, during July 2016. June 2018. We identified isolates by using the GeneXpert platform to evaluate drug-resistance profiles. A total of 191 (62%) of 309 isolates had rifampin resistance; 168 (88%) of these rifampin-resistant isolates were not genomically related, indicating the repeated emergence of resistance in the population, rather than extensive local transmission. We did not detect resistance mutations to new oral drugs, including bedaquiline and pretomanid. The current GeneXpert MTB/RIF system needs to be modified by using the newly launched Xpert MTB/XDR cartridge or line-probe assay. Introducing new oral drugs to replace those currently used in treatment regimens for multidrug-resistant TB will also be useful for treating TB in Myanmar.
ISSN: 1080-6040
DOI: 10.3201/eid2711.210726
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: This is an open-access article distributed under the terms of the Creative Commons Attribution License.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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