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Title: Role of anterior segment optical coherence tomography angiography in the assessment of acute chemical ocular injury : a pilot animal model study
Authors: Tey, Kai Yuan
Gan, Jinyuan
Foo, Valencia
Tan, Bingyao
Ke, Meng Yuan
Schmetterer, Leopold
Mehta, Jodhbir S.
Ang, Marcus
Keywords: Science::Medicine
Issue Date: 2021
Source: Tey, K. Y., Gan, J., Foo, V., Tan, B., Ke, M. Y., Schmetterer, L., Mehta, J. S. & Ang, M. (2021). Role of anterior segment optical coherence tomography angiography in the assessment of acute chemical ocular injury : a pilot animal model study. Scientific Reports, 11(1), 16625-.
Project: CG/C010A/2017
Journal: Scientific Reports 
Abstract: To examine the use of anterior segment-optical coherence tomography angiography (AS-OCTA) in the assessment of limbal ischemia in an animal model chemical ocular injury. We conducted a prospective study using an established chemical ocular injury model in 6 rabbits (12 eyes), dividing the cornea limbus into 4 quadrants. Chemical injury grade was induced based on extent of limbal injury (0 to 360 degrees) and all eyes underwent serial slit-lamp with AS-OCTA imaging up to one month. Main outcome measure was changes in AS-OCTA vessel density (VD) comparing injured and control cornea limbal quadrants within 24 h and at one month. AS-OCTA was able to detect differences in limbal VD reduction comparing injured (3.3 ± 2.4%) and control quadrants (7.6 ± 2.3%; p < 0.001) within 24 h of ocular chemical injury. We also observed that AS-OCTA VD reduction was highly correlated with the number of quadrants injured (r = - 0.89; p < 0.001; 95% CI - 5.65 to - 1.87). Corneal vascularization was detected by AS-OCTA in injured compared to control quadrants (10.1 ± 4.3% vs 7.0 ± 1.2%; p = 0.025) at 1 month. Our animal pilot study suggests that AS-OCTA was able to detect limbal vessel disruption from various severities of acute chemical insult, and in the future, could potentially serve as an adjunct in providing objective grading of acute ocular chemical injury once validated in a clinical trial.
ISSN: 2045-2322
DOI: 10.1038/s41598-021-96086-0
Rights: © 2021 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
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