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Title: Evolution, heterogeneity and global dispersal of cosmopolitan genotype of Dengue virus type 2
Authors: Yenamandra, Surya Pavan
Koo, Carmen
Chiang, Suzanna
Lim, Jeri Han Shi
Yeo, Zhen Yuan
Ng, Lee Ching
Hapuarachchi, Hapuarachchige Chanditha
Keywords: Science::Biological sciences
Issue Date: 2021
Source: Yenamandra, S. P., Koo, C., Chiang, S., Lim, J. H. S., Yeo, Z. Y., Ng, L. C. & Hapuarachchi, H. C. (2021). Evolution, heterogeneity and global dispersal of cosmopolitan genotype of Dengue virus type 2. Scientific Reports, 11(1), 13496-.
Journal: Scientific Reports
Abstract: Dengue virus type 2 (DENV-2) contributes substantially to the dengue burden and dengue-related mortality in the tropics and sub-tropics. DENV-2 includes six genotypes, among which cosmopolitan genotype is the most widespread. The present study investigated the evolution, intra-genotype heterogeneity and dispersal of cosmopolitan genotype to understand unique genetic characteristics that have shaped the molecular epidemiology and distribution of cosmopolitan lineages. The spatial analysis demonstrated a wide geo-distribution of cosmopolitan genotype through an extensive inter-continental network, anchored in Southeast Asia and Indian sub-continent. Intra-genotype analyses using 3367 envelope gene sequences revealed six distinct lineages within the cosmopolitan genotype, namely the Indian sub-continent lineage and five other lineages. Indian sub-continent lineage was the most diverged among six lineages and has almost reached the nucleotide divergence threshold of 6% within E gene to qualify as a separate genotype. Genome wide amino acid signatures and selection pressure analyses further suggested differences in evolutionary characteristics between the Indian sub-continent lineage and other lineages. The present study narrates a comprehensive genomic analysis of cosmopolitan genotype and presents notable genetic characteristics that occurred during its evolution and global expansion. Whether those characteristics conferred a fitness advantage to cosmopolitan genotype in different geographies warrant further investigations.
ISSN: 2045-2322
DOI: 10.1038/s41598-021-92783-y
Rights: © 2021 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
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