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Title: Topological encoded vector beams for monitoring amyloid - lipid interactions in microcavity
Authors: Gong, Chaoyang
Qiao, Zhen
Yuan, Zhiyi
Huang, Shih-Hsiu
Wang, Wenjie
Wu, Pin Chieh
Chen, Yu-Cheng
Keywords: Engineering::Electrical and electronic engineering
Engineering::Chemical engineering
Issue Date: 2021
Source: Gong, C., Qiao, Z., Yuan, Z., Huang, S., Wang, W., Wu, P. C. & Chen, Y. (2021). Topological encoded vector beams for monitoring amyloid - lipid interactions in microcavity. Advanced Science, 8(12), 2100096-.
Project: A20E5c0085
Journal: Advanced Science 
Abstract: Lasers are the pillars of modern photonics and sensing. Recent advances in microlasers have demonstrated its extraordinary lasing characteristics suitable for biosensing. However, most lasers utilized lasing spectrum as a detection signal, which can hardly detect or characterize nanoscale structural changes in microcavity. Here the concept of amplified structured light-molecule interactions is introduced to monitor tiny bio-structural changes in a microcavity. Biomimetic liquid crystal droplets with self-assembled lipid monolayers are sandwiched in a Fabry-Pérot cavity, where subtle protein-lipid membrane interactions trigger the topological transformation of output vector beams. By exploiting Amyloid β (Aβ)-lipid membrane interactions as a proof-of-concept, it is demonstrated that vector laser beams can be viewed as a topology of complex laser modes and polarization states. The concept of topological-encoded laser barcodes is therefore developed to reveal dynamic changes of laser modes and Aβ-lipid interactions with different Aβ assembly structures. The findings demonstrate that the topology of vector beams represents significant features of intracavity nano-structural dynamics resulted from structured light-molecule interactions.
ISSN: 2198-3844
DOI: 10.1002/advs.202100096
Rights: © 2021 The Authors. Advanced Science published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:EEE Journal Articles
SCBE Journal Articles

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