Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/153800
Title: Dynamics of the fecal microbiome and antimicrobial resistome in commercial piglets during the weaning period
Authors: Suriyaphol, Prapat
Chiu, Jimmy Ka Ho
Yimpring, Nathamon
Tunsagool, Paiboon
Mhuantong, Wuttichai
Chuanchuen, Rungtip
Bessarab, Irina
Williams, Rohan B. H.
Ong, Rick Twee-Hee
Suriyaphol, Gunnaporn
Keywords: Engineering::Environmental engineering
Science::Biological sciences
Issue Date: 2021
Source: Suriyaphol, P., Chiu, J. K. H., Yimpring, N., Tunsagool, P., Mhuantong, W., Chuanchuen, R., Bessarab, I., Williams, R. B. H., Ong, R. T. & Suriyaphol, G. (2021). Dynamics of the fecal microbiome and antimicrobial resistome in commercial piglets during the weaning period. Scientific Reports, 11(1), 18091-. https://dx.doi.org/10.1038/s41598-021-97586-9
Journal: Scientific Reports 
Abstract: This study aimed to characterize the alteration of the fecal microbiome and antimicrobial resistance (AMR) determinants in 24 piglets at day 3 pre-weaning (D. - 3), weaning day (D.0), days 3 (D.3) and 8 post-weaning (D.8), using whole-genome shotgun sequencing. Distinct clusters of microbiomes and AMR determinants were observed at D.8 when Prevotella (20.9%) was the major genus, whereas at D. - 3-D.3, Alistipes (6.9-12.7%) and Bacteroides (5.2-8.5%) were the major genera. Lactobacillus and Escherichia were notably observed at D. - 3 (1.2%) and D. - 3-D.3 (0.2-0.4%), respectively. For AMR, a distinct cluster of AMR determinants was observed at D.8, mainly conferring resistance to macrolide-lincosamide-streptogramin (mefA), β-lactam (cfxA6 and aci1) and phenicol (rlmN). In contrast, at D. - 3-D.3, a high abundance of determinants with aminoglycoside (AMG) (sat, aac(6')-aph(2''), aadA and acrF), β-lactam (fus-1, cepA and mrdA), multidrug resistance (MDR) (gadW, mdtE, emrA, evgS, tolC and mdtB), phenicol (catB4 and cmlA4), and sulfonamide patterns (sul3) was observed. Canonical correlation analysis (CCA) plot associated Escherichia coli with aac(6')-aph(2''), emrA, mdtB, catB4 and cmlA4 at D. - 3, D.0 and/or D.3 whereas at D.8 associations between Prevotella and mefA, cfxA6 and aci1 were identified. The weaning age and diet factor played an important role in the microbial community composition.
URI: https://hdl.handle.net/10356/153800
ISSN: 2045-2322
DOI: 10.1038/s41598-021-97586-9
Rights: © 2021 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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