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Title: A neurogenic microenvironment defined by excitatory-inhibitory neuronal circuits in adult dentate gyrus
Authors: Uemura, Masato
Blankvoort, Stefan
Tok, Sean Shui Liang
Yuan, Li
Cobar, Luis Fernando
Lit, Kwok Keung
Tashiro, Ayumu
Keywords: Science::Biological sciences
Issue Date: 2021
Source: Uemura, M., Blankvoort, S., Tok, S. S. L., Yuan, L., Cobar, L. F., Lit, K. K. & Tashiro, A. (2021). A neurogenic microenvironment defined by excitatory-inhibitory neuronal circuits in adult dentate gyrus. Cell Reports, 36(1), 109324-.
Project: MOE2015-T2-2-035 
Journal: Cell Reports
Abstract: Adult neurogenesis in the dentate gyrus plays a role in adaptive brain functions such as memory formation. Adding new neurons to a specific locus of a neural circuit with functional needs is an efficient way to achieve such an adaptive function. However, it is unknown whether neurogenesis is linked to local functional demands potentially specified by the activity of neuronal circuits. By examining the distribution of neurogenesis and different types of neuronal activity in the dentate gyrus of freely moving adult rats, we find that neurogenesis is positionally associated with active excitatory neurons, some of which show place-cell activity, but is positionally dissociated from a type of interneuron with high-burst tendency. Our finding suggests that the behaviorally relevant activity of excitatory-inhibitory neuronal circuits can define a microenvironment stimulating/inhibiting neurogenesis. Such local regulation of neurogenesis may contribute to strategic recruitment of new neurons to modify functionally relevant neural circuits.
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2021.109324
Rights: © 2021 The Author(s). This is an open access article under the CC BY-NC-ND license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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