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https://hdl.handle.net/10356/153813
Title: | A neurogenic microenvironment defined by excitatory-inhibitory neuronal circuits in adult dentate gyrus | Authors: | Uemura, Masato Blankvoort, Stefan Tok, Sean Shui Liang Yuan, Li Cobar, Luis Fernando Lit, Kwok Keung Tashiro, Ayumu |
Keywords: | Science::Biological sciences | Issue Date: | 2021 | Source: | Uemura, M., Blankvoort, S., Tok, S. S. L., Yuan, L., Cobar, L. F., Lit, K. K. & Tashiro, A. (2021). A neurogenic microenvironment defined by excitatory-inhibitory neuronal circuits in adult dentate gyrus. Cell Reports, 36(1), 109324-. https://dx.doi.org/10.1016/j.celrep.2021.109324 | Project: | MOE2015-T2-2-035 MOE2017-T3-1-002 NIM/02/2016 NMRC/OFIRG/0046/2017 |
Journal: | Cell Reports | Abstract: | Adult neurogenesis in the dentate gyrus plays a role in adaptive brain functions such as memory formation. Adding new neurons to a specific locus of a neural circuit with functional needs is an efficient way to achieve such an adaptive function. However, it is unknown whether neurogenesis is linked to local functional demands potentially specified by the activity of neuronal circuits. By examining the distribution of neurogenesis and different types of neuronal activity in the dentate gyrus of freely moving adult rats, we find that neurogenesis is positionally associated with active excitatory neurons, some of which show place-cell activity, but is positionally dissociated from a type of interneuron with high-burst tendency. Our finding suggests that the behaviorally relevant activity of excitatory-inhibitory neuronal circuits can define a microenvironment stimulating/inhibiting neurogenesis. Such local regulation of neurogenesis may contribute to strategic recruitment of new neurons to modify functionally relevant neural circuits. | URI: | https://hdl.handle.net/10356/153813 | ISSN: | 2211-1247 | DOI: | 10.1016/j.celrep.2021.109324 | Schools: | School of Biological Sciences | Rights: | © 2021 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | SBS Journal Articles |
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PIIS2211124721007002.pdf | 4.76 MB | Adobe PDF | View/Open |
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