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Title: Formin nanoclustering-mediated actin assembly during plant flagellin and DSF signaling
Authors: Ma, Zhiming
Liu, Xiaolin
Nath, Sangeeta
Sun, He
Tran, Tuan Minh
Yang, Liang
Mayor, Satyajit
Miao, Yansong
Keywords: Science::Biological sciences
Issue Date: 2021
Source: Ma, Z., Liu, X., Nath, S., Sun, H., Tran, T. M., Yang, L., Mayor, S. & Miao, Y. (2021). Formin nanoclustering-mediated actin assembly during plant flagellin and DSF signaling. Cell Reports, 34(13), 108884-.
Project: M4081533 
Journal: Cell Reports 
Abstract: Plants respond to bacterial infection acutely with actin remodeling during plant immune responses. The mechanisms by which bacterial virulence factors (VFs) modulate plant actin polymerization remain enigmatic. Here, we show that plant-type-I formin serves as the molecular sensor for actin remodeling in response to two bacterial VFs: Xanthomonas campestris pv. campestris (Xcc) diffusible signal factor (DSF), and pathogen-associated molecular pattern (PAMP) flagellin in pattern-triggered immunity (PTI). Both VFs regulate actin assembly by tuning the clustering and nucleation activity of formin on the plasma membrane (PM) at the nano-sized scale. By being integrated within the cell-wall-PM-actin cytoskeleton (CW-PM-AC) continuum, the dynamic behavior and function of formins are highly dependent on each scaffold layer's composition within the CW-PM-AC continuum during both DSF and PTI signaling. Our results reveal a central mechanism for rapid actin remodeling during plant-bacteria interactions, in which bacterial signaling molecules fine tune plant formin nanoclustering in a host mechanical-structure-dependent manner.
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2021.108884
Rights: © 2021 The Author(s). This is an open access article under the CC BY license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles
SCELSE Journal Articles

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