Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/153841
Title: | Antimicrobial effect of a novel chitosan derivative and its synergistic effect with antibiotics | Authors: | Si, Zhangyong Hou, Zheng Vikhe, Yogesh Shankar Thappeta, Kishore Reddy Venkata Marimuthu, Kalisvar De, Partha Pratim Ng, Oon Tek Li, Peng Zhu, Yabin Pethe, Kevin Chan-Park, Mary B. |
Keywords: | Engineering::Chemical engineering::Polymers and polymer manufacture | Issue Date: | 2021 | Source: | Si, Z., Hou, Z., Vikhe, Y. S., Thappeta, K. R. V., Marimuthu, K., De, P. P., Ng, O. T., Li, P., Zhu, Y., Pethe, K. & Chan-Park, M. B. (2021). Antimicrobial effect of a novel chitosan derivative and its synergistic effect with antibiotics. ACS Applied Materials & Interfaces, 13(2), 3237-3245. https://dx.doi.org/10.1021/acsami.0c20881 | Project: | MOE2013-T3-1-002 MOE2018-T3-1-003 NMRC/MOHIAFCAT2/003/2014 H17/01/a0/ 0M9 A1786a0032 |
Journal: | ACS Applied Materials & Interfaces | Abstract: | Cationic polymers are promising antibacterial agents since they have a low propensity for bacteria to evolve resistance, but they usually have low biocompatibility due to their hydrophobic moieties. Herein, we report a new biodegradable and biocompatible chitosan-derived cationic antibacterial polymer, 2,6-Diamino Chitosan (2,6-DAC). 2,6-DAC shows excellent broad-spectrum antimicrobial activity with minimum inhibitory concentrations (MICs) of 8-32 µg/mL against clinically relevant and multi-drug resistant (MDR) bacteria including Listeria monocytogenes, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii. Further, 2,6-DAC shows an excellent synergistic effect with various clinically relevant antibiotics proved by decreasing the MICs of the antibiotics against MDR A. baumannii and MRSA to <1 µg/mL. In vivo biocompatibility of 2,6-DAC is proved by a dosage of 100 mg/kg compound via the oral administration and 25 mg/kg compound via intraperitoneal injection to mice; 2,6-DAC does not cause any weight loss and any significant change in liver and kidney biomarkers nor the important blood electrolytes. The combinations of 2,6-DAC together with novobiocin and rifampicin show >2.4 log10 reduction of A. baumannii in murine intraperitoneal and lung infection models. The novel chitosan derivative, 2,6-DAC, can be utilized as biocompatible broad-spectrum cationic antimicrobial agent alone or in synergistic combination with various antibiotics. | URI: | https://hdl.handle.net/10356/153841 | ISSN: | 1944-8244 | DOI: | 10.1021/acsami.0c20881 | Schools: | School of Chemical and Biomedical Engineering Lee Kong Chian School of Medicine (LKCMedicine) School of Biological Sciences |
Research Centres: | Centre for Antimicrobial Bioengineering | Rights: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials & Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsami.0c20881. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | LKCMedicine Journal Articles SBS Journal Articles SCBE Journal Articles |
Files in This Item:
File | Description | Size | Format | |
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Manuscript.pdf | Main | 934.12 kB | Adobe PDF | ![]() View/Open |
Supporting information.pdf | SI | 2.61 MB | Adobe PDF | ![]() View/Open |
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