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https://hdl.handle.net/10356/153866| Title: | Stool metagenome analysis of patients with Klebsiella pneumoniae liver abscess and their domestic partners | Authors: | Molton, James S. Lee, I. Russel Bertrand, Denis Ding, Ying Kalimuddin, Shirin Lye, David C. Nagarajan, Niranjan Gan, Yunn-Hwen Archuleta, Sophia |
Keywords: | Science::Medicine | Issue Date: | 2021 | Source: | Molton, J. S., Lee, I. R., Bertrand, D., Ding, Y., Kalimuddin, S., Lye, D. C., Nagarajan, N., Gan, Y. & Archuleta, S. (2021). Stool metagenome analysis of patients with Klebsiella pneumoniae liver abscess and their domestic partners. International Journal of Infectious Diseases, 107, 1-4. https://dx.doi.org/10.1016/j.ijid.2021.04.012 | Project: | SIDI/2016/0 03 | Journal: | International Journal of Infectious Diseases | Abstract: | Objectives: Hypermucoviscous Klebsiella pneumoniae is an emerging cause of community-acquired liver abscess. The aim of this study was to investigate whether hypermucoviscous strains could be shared among households. Methods: The clinical K. pneumoniae isolates from a cohort of 24 patients with Klebsiella liver abscess were genotyped, and the stool metagenomes of the index patients and their cohabiting domestic partners were analyzed. Results: K. pneumoniae was identified in 33% of index patient stools, and one index patient's clinical isolate was identified in their domestic partner's stool. Conclusions: This could represent a transmission event or could represent exposure to a common environmental source. (C) 2021 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. | URI: | https://hdl.handle.net/10356/153866 | ISSN: | 1201-9712 | DOI: | 10.1016/j.ijid.2021.04.012 | Rights: | © 2021 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-ncnd/4.0/). | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
| Appears in Collections: | LKCMedicine Journal Articles |
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| 1-s2.0-S1201971221003234.pdf | 424.05 kB | Adobe PDF | View/Open |
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