Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/153870
Title: Transient transmission of Chikungunya virus in Singapore exemplifies successful mitigation of severe epidemics in a vulnerable population
Authors: Hapuarachchi, Hapuarachchige Chanditha
Wong, Wing-Yan
Koo, Carmen
Tien, Wei-Ping
Yeo, Gladys
Rajarethinam, Jayanthi
Tan, Eugene
Chiang, Suzanna
Chong, Chee-Seng
Tan, Cheong-Huat
Tan, Li-Kiang
Ng, Lee Ching
Keywords: Science::Biological sciences
Issue Date: 2021
Source: Hapuarachchi, H. C., Wong, W., Koo, C., Tien, W., Yeo, G., Rajarethinam, J., Tan, E., Chiang, S., Chong, C., Tan, C., Tan, L. & Ng, L. C. (2021). Transient transmission of Chikungunya virus in Singapore exemplifies successful mitigation of severe epidemics in a vulnerable population. International Journal of Infectious Diseases, 110, 417-425. https://dx.doi.org/10.1016/j.ijid.2021.08.007
Journal: International Journal of Infectious Diseases
Abstract: Objectives: Singapore experienced two major outbreaks of chikungunya in 2008-09 and 2013-14. Despite repeated virus introductions, fresh local outbreaks have not emerged after 2014. The present study reviews the success of chikungunya control in Singapore, despite repeated introduction of virus strains, presence of competent vectors and an immunologically naive population. Methods: Chikungunya virus (CHIKV) sequences (421 envelope 1 genes and 56 polyproteins) were analysed to distinguish the indigenous virus groups from 2008 to 2020. Vector surveillance data was used to incriminate the vector/s associated with local outbreaks. The population exposure to CHIKV was determined by assessing the seroprevalence status in three cohorts of sera collected in 2009 (n = 2,008), 2013 (n = 2,0 0 0) and 2017 (n = 3,615). Results: Four distinct groups of CHIKV of East, Central and South African genotype have mainly circulated since 2008, transmitted primarily by Aedes albopictus. The age weighted CHIKV IgG prevalence rates were low (1-5%) and showed a non-significant increase from 2009 to 2013, but a significant decrease in 2017. In contrast, the prevalence of CHIKV neutralising antibodies in the population increased significantly from 2009 to 2013, with no significant change in 2017, but the levels remained below 2%. Conclusions: The evidence suggested that surveillance and vector control strategies implemented were robust to avert severe epidemics, despite repeated introduction of virus strains, presence of competent vectors and an immunologically naive population.
URI: https://hdl.handle.net/10356/153870
ISSN: 1201-9712
DOI: 10.1016/j.ijid.2021.08.007
Rights: © 2021 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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