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Title: Bulges in left-handed G-quadruplexes
Authors: Das, Poulomi
Ngo, Khac Huy
Winnerdy, Fernaldo Richtia
Maity, Arijit
Bakalar, Blaž
Mechulam, Yves
Schmitt, Emmanuelle
Phan, Anh Tuân
Keywords: Science::Biological sciences
Issue Date: 2021
Source: Das, P., Ngo, K. H., Winnerdy, F. R., Maity, A., Bakalar, B., Mechulam, Y., Schmitt, E. & Phan, A. T. (2021). Bulges in left-handed G-quadruplexes. Nucleic Acids Research, 49(3), 1724-1736.
Project: NRF-NRFI2017-09
Journal: Nucleic Acids Research
Abstract: G-quadruplex (G4) DNA structures with a left-handed backbone progression have unique and conserved structural features. Studies on sequence dependency of the structures revealed the prerequisites and some minimal motifs required for left-handed G4 formation. To extend the boundaries, we explore the adaptability of left-handed G4s towards the existence of bulges. Here we present two X-ray crystal structures and an NMR solution structure of left-handed G4s accommodating one, two and three bulges. Bulges in left-handed G4s show distinct characteristics as compared to those in right-handed G4s. The elucidation of intricate structural details will help in understanding the possible roles and limitations of these unique structures.
ISSN: 0305-1048
DOI: 10.1093/nar/gkaa1259
Rights: © 2021 The Author(s). Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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