Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/153872
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dc.contributor.authorDas, Poulomien_US
dc.contributor.authorNgo, Khac Huyen_US
dc.contributor.authorWinnerdy, Fernaldo Richtiaen_US
dc.contributor.authorMaity, Arijiten_US
dc.contributor.authorBakalar, Blažen_US
dc.contributor.authorMechulam, Yvesen_US
dc.contributor.authorSchmitt, Emmanuelleen_US
dc.contributor.authorPhan, Anh Tuânen_US
dc.date.accessioned2021-12-16T07:18:18Z-
dc.date.available2021-12-16T07:18:18Z-
dc.date.issued2021-
dc.identifier.citationDas, P., Ngo, K. H., Winnerdy, F. R., Maity, A., Bakalar, B., Mechulam, Y., Schmitt, E. & Phan, A. T. (2021). Bulges in left-handed G-quadruplexes. Nucleic Acids Research, 49(3), 1724-1736. https://dx.doi.org/10.1093/nar/gkaa1259en_US
dc.identifier.issn0305-1048en_US
dc.identifier.urihttps://hdl.handle.net/10356/153872-
dc.description.abstractG-quadruplex (G4) DNA structures with a left-handed backbone progression have unique and conserved structural features. Studies on sequence dependency of the structures revealed the prerequisites and some minimal motifs required for left-handed G4 formation. To extend the boundaries, we explore the adaptability of left-handed G4s towards the existence of bulges. Here we present two X-ray crystal structures and an NMR solution structure of left-handed G4s accommodating one, two and three bulges. Bulges in left-handed G4s show distinct characteristics as compared to those in right-handed G4s. The elucidation of intricate structural details will help in understanding the possible roles and limitations of these unique structures.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.description.sponsorshipNanyang Technological Universityen_US
dc.description.sponsorshipNational Research Foundation (NRF)en_US
dc.language.isoenen_US
dc.relationNRF-NRFI2017-09en_US
dc.relationMOE2015-T21092en_US
dc.relation.ispartofNucleic Acids Researchen_US
dc.rights© 2021 The Author(s). Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.subjectScience::Biological sciencesen_US
dc.titleBulges in left-handed G-quadruplexesen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.contributor.organizationNTU Institute of Structural Biologyen_US
dc.identifier.doi10.1093/nar/gkaa1259-
dc.description.versionPublished versionen_US
dc.identifier.pmid33503265-
dc.identifier.scopus2-s2.0-85102216172-
dc.identifier.issue3en_US
dc.identifier.volume49en_US
dc.identifier.spage1724en_US
dc.identifier.epage1736en_US
dc.subject.keywordsCrystallographyen_US
dc.subject.keywordsX-Rayen_US
dc.description.acknowledgementSingapore National Research Foundation Investigatorship [NRF-NRFI2017-09]; Singapore Ministry of Education Academic Research Fund Tier 2 [MOE2015-T2- 1092]; Nanyang Technological University (NTU Singapore) grants (to A.T.P.). Funding for open access charge: Nanyang Technological University.en_US
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