Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/15389
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLee, Lan Yin.-
dc.date.accessioned2009-04-28T02:44:16Z-
dc.date.available2009-04-28T02:44:16Z-
dc.date.copyright2009-
dc.date.issued2009-
dc.identifier.urihttp://hdl.handle.net/10356/15389-
dc.description.abstractHerein, the synthesis and evaluation of a new group of biodegradable elastomeric polyesters, poly(1, 12-dodecandiol-co-malic acid) is performed. The main objectives of this project are to design a malic acid-based aliphatic polyester material with desirable modulus, elasticity and degradation rate. Two-dimensional poly(1, 12-dodecandiol-co-malic acid) scaffolds were prepared by reacting malic acid with different diol ratios under nitrogen flow to form pre-polymers. Pre-polymers were then post-polymerized at 140oC and 160oC under vacuum (30 kPa) for various days. 8 scaffolds with different acid to diol ratios were synthesized and post-polymerization under different conditions and then characterized. All scaffolds demonstrated good thermal stability. Seven out of eight materials passed the in vitro cytotoxicity test with the Young’s modulus ranged from 1.13±0.65MPa to 4.04±0.78MPa. Elongation was as high as 1070.48±265.14%. The mechanical properties and degradation rate could be controlled by choosing different acid to diol ratios as well as by modulating the post-polymerization conditions. In addition, this study would like to propose PDDM1-1,21,0 and PDDM1-2,36,0 for further investigation as they showed desirable thermal and mechanical properties, degradation rate and excellent results for cell growth.en_US
dc.format.extent49 p.en_US
dc.language.isoenen_US
dc.rightsNanyang Technological University-
dc.subjectDRNTU::Engineering::Materials::Biomaterialsen_US
dc.titleSynthesis and characterization of biodegradable elastomers for soft tissue engineeringen_US
dc.typeFinal Year Project (FYP)en_US
dc.contributor.supervisorTan Lay Pohen_US
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.description.degreeBachelor of Engineering (Materials Engineering)en_US
item.fulltextWith Fulltext-
item.grantfulltextrestricted-
Appears in Collections:MSE Student Reports (FYP/IA/PA/PI)
Files in This Item:
File Description SizeFormat 
MSE08-091.pdf
  Restricted Access
1.36 MBAdobe PDFView/Open

Google ScholarTM

Check

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.