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Title: A synbiotic intervention modulates meta-omics signatures of gut redox potential and acidity in elective caesarean born infants
Authors: Lay, Christophe
Chu, Collins Wenhan
Purbojati, Rikky Wenang
Acerbi, Enzo
Drautz-Moses, Daniela Isabel
de Sessions, Paola Florez
Jie, Song
Ho, Eliza
Kok, Yee Jiun
Bi, Xuezhi
Chen, Shuwen
Mak, Shi Ya
Chua, Mei Chien
Goh, Anne E. N.
Chiang, Wen Chin
Rao, Rajeshwar
Chaithongwongwatthana, Surasith
Khemapech, Nipon
Chongsrisawat, Voranush
Martin, Rocio
JULIUS Study Group, Guus Roeselers
Ho, Ying Swan
Hibberd, Martin L.
Schuster, Stephan Christoph
Knol, Jan
Keywords: Engineering::Environmental engineering
Issue Date: 2021
Source: Lay, C., Chu, C. W., Purbojati, R. W., Acerbi, E., Drautz-Moses, D. I., de Sessions, P. F., Jie, S., Ho, E., Kok, Y. J., Bi, X., Chen, S., Mak, S. Y., Chua, M. C., Goh, A. E. N., Chiang, W. C., Rao, R., Chaithongwongwatthana, S., Khemapech, N., Chongsrisawat, V., ...Knol, J. (2021). A synbiotic intervention modulates meta-omics signatures of gut redox potential and acidity in elective caesarean born infants. BMC Microbiology, 21(1), 191-.
Project: IAF111135 
Journal: BMC Microbiology 
Abstract: The compromised gut microbiome that results from C-section birth has been hypothesized as a risk factor for the development of non-communicable diseases (NCD). In a double-blind randomized controlled study, 153 infants born by elective C-section received an infant formula supplemented with either synbiotic, prebiotics, or unsupplemented from birth until 4 months old. Vaginally born infants were included as a reference group. Stool samples were collected from day 3 till week 22. Multi-omics were deployed to investigate the impact of mode of delivery and nutrition on the development of the infant gut microbiome, and uncover putative biological mechanisms underlying the role of a compromised microbiome as a risk factor for NCD.
ISSN: 1471-2180
DOI: 10.1186/s12866-021-02230-1
Rights: © 2021 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCELSE Journal Articles

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