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dc.contributor.authorLim, Li Mingen_US
dc.contributor.authorHadinoto, Kunnen_US
dc.identifier.citationLim, L. M. & Hadinoto, K. (2021). High-payload buccal delivery system of amorphous curcumin-chitosan nanoparticle complex in hydroxypropyl methylcellulose and starch films. International Journal of Molecular Sciences, 22(17), 9399-.
dc.description.abstractOral delivery of curcumin (CUR) has limited effectiveness due to CUR's poor systemic bioavailability caused by its first-pass metabolism and low solubility. Buccal delivery of CUR nanoparticles can address the poor bioavailability issue by virtue of avoidance of first-pass metabolism and solubility enhancement afforded by CUR nanoparticles. Buccal film delivery of drug nanoparticles, nevertheless, has been limited to low drug payload. Herein, we evaluated the feasibilities of three mucoadhesive polysaccharides, i.e., hydroxypropyl methylcellulose (HPMC), starch, and hydroxypropyl starch as buccal films of amorphous CUR-chitosan nanoplex at high CUR payload. Both HPMC and starch films could accommodate high CUR payload without adverse effects on the films' characteristics. Starch films exhibited far superior CUR release profiles at high CUR payload as the faster disintegration time of starch films lowered the precipitation propensity of the highly supersaturated CUR concentration generated by the nanoplex. Compared to unmodified starch, hydroxypropyl starch films exhibited superior CUR release, with sustained release of nearly 100% of the CUR payload in 4 h. Hydroxypropyl starch films also exhibited good payload uniformity, minimal weight/thickness variations, high folding endurance, and good long-term storage stability. The present results established hydroxypropyl starch as the suitable mucoadhesive polysaccharide for high-payload buccal film applications.en_US
dc.description.sponsorshipNanyang Technological Universityen_US
dc.relationNRP SCBE01jr 2017en_US
dc.relation.ispartofInternational Journal of Molecular Sciencesen_US
dc.rights© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
dc.subjectEngineering::Chemical engineeringen_US
dc.titleHigh-payload buccal delivery system of amorphous curcumin-chitosan nanoparticle complex in hydroxypropyl methylcellulose and starch filmsen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.description.versionPublished versionen_US
dc.subject.keywordsNanoparticle Complexen_US
dc.description.acknowledgementThis work was funded by the Nanyang Research Programme (NRP SCBE01jr 2017) of Nanyang Technological University, Singapore.en_US
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