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Title: Genome wide study of tardive dyskinesia in schizophrenia
Authors: Lim, Keane
Lam, Max
Zai, Clement
Tay, Jenny
Karlsson, Nina
Deshpande, Smita N.
Thelma, B. K.
Ozaki, Norio
Inada, Toshiya
Sim, Kang
Chong, Siow-Ann
Lencz, Todd
Liu, Jianjun
Lee, Jimmy
Keywords: Science::Medicine
Issue Date: 2021
Source: Lim, K., Lam, M., Zai, C., Tay, J., Karlsson, N., Deshpande, S. N., Thelma, B. K., Ozaki, N., Inada, T., Sim, K., Chong, S., Lencz, T., Liu, J. & Lee, J. (2021). Genome wide study of tardive dyskinesia in schizophrenia. Translational Psychiatry, 11(1), 351-.
Project: NMRC/CG/ 004/2013
Journal: Translational Psychiatry
Abstract: Tardive dyskinesia (TD) is a severe condition characterized by repetitive involuntary movement of orofacial regions and extremities. Patients treated with antipsychotics typically present with TD symptomatology. Here, we conducted the largest GWAS of TD to date, by meta-analyzing samples of East-Asian, European, and African American ancestry, followed by analyses of biological pathways and polygenic risk with related phenotypes. We identified a novel locus and three suggestive loci, implicating immune-related pathways. Through integrating trans-ethnic fine mapping, we identified putative credible causal variants for three of the loci. Post-hoc analysis revealed that SNPs harbored in TNFRSF1B and CALCOCO1 independently conferred three-fold increase in TD risk, beyond clinical risk factors like Age of onset and Duration of illness to schizophrenia. Further work is necessary to replicate loci that are reported in the study and evaluate the polygenic architecture underlying TD.
ISSN: 2158-3188
DOI: 10.1038/s41398-021-01471-y
Rights: © 2021 The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
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