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Title: Nontoxic antimicrobial cationic peptide nanoconstructs with bacteria-displaceable polymeric counteranions
Authors: Pranantyo, Dicky
Raju, Cheerlavancha
Si, Zhangyong
Xu, Xiaofei
Pethe, Kevin
Kang, En-Tang
Chan-Park, Mary B.
Keywords: Engineering::Chemical engineering::Polymers and polymer manufacture
Issue Date: 2021
Source: Pranantyo, D., Raju, C., Si, Z., Xu, X., Pethe, K., Kang, E. & Chan-Park, M. B. (2021). Nontoxic antimicrobial cationic peptide nanoconstructs with bacteria-displaceable polymeric counteranions. Nano Letters, 21(2), 899-906.
Project: MOE2013-T3-1-002
Journal: Nano Letters 
Abstract: Antimicrobial peptides that target the integrity of bacterial envelopes can eradicate pathogens with little development of resistance, but they often inflict nonselective toxicity toward mammalian cells. The prevailing approach to optimize the selectivity of cationic peptides has been to modify their composition. Instead, we invent a new generation of broad-spectrum antibacterial nanoconstructs with negligible mammalian cell toxicity through a competitive displacement of counter polyanions from the complementary polycations. The nanoconstruct, which has a highly cationic Au nanoparticles (NPs) core shielded by polymeric counterions, is inert in nonbacterial environments. When exposed to negatively charged bacterial envelopes, this construct sheds its polyanions, triggering a cationic Au NP/bacterial membrane interaction that rapidly kills Gram-positive and Gram-negative bacteria. The anionic charge and hydrophilicity of the polyanion provides charge neutralization for the peptide-decorated Au NP core, but it is also bacteria-displaceable. These results provide a foundation for the development of other cationic particles and polymeric counterion combinations with potent antimicrobial activity without toxicity.
ISSN: 1530-6984
DOI: 10.1021/acs.nanolett.0c03261
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Nano Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Fulltext Permission: embargo_20220204
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles
SCBE Journal Articles
SPMS Journal Articles

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