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Title: Fixel-based analysis effectively identifies white matter tract degeneration in Huntington's disease
Authors: Oh, Sher Li
Chen, Chiung-Mei
Wu, Yih-Ru
Hernandez, Maria Valdes
Tsai, Chih-Chien
Cheng, Jur-Shan
Chen, Yao-Liang
Wu, Yi-Ming
Lin, Yu-Chun
Wang, Jiun-Jie
Keywords: Science::Medicine
Issue Date: 2021
Source: Oh, S. L., Chen, C., Wu, Y., Hernandez, M. V., Tsai, C., Cheng, J., Chen, Y., Wu, Y., Lin, Y. & Wang, J. (2021). Fixel-based analysis effectively identifies white matter tract degeneration in Huntington's disease. Frontiers in Neuroscience, 15, 711651-.
Journal: Frontiers in Neuroscience 
Abstract: Microstructure damage in white matter might be linked to regional and global atrophy in Huntington's Disease (HD). We hypothesize that degeneration of subcortical regions, including the basal ganglia, is associated with damage of white matter tracts linking these affected regions. We aim to use fixel-based analysis to identify microstructural changes in the white matter tracts. To further assess the associated gray matter damage, diffusion tensor-derived indices were measured from regions of interest located in the basal ganglia. Diffusion weighted images were acquired from 12 patients with HD and 12 healthy unrelated controls using a 3 Tesla scanner. Reductions in fixel-derived metrics occurs in major white matter tracts, noticeably in corpus callosum, internal capsule, and the corticospinal tract, which were closely co-localized with the regions of increased diffusivity in basal ganglia. These changes in diffusion can be attributed to potential axonal degeneration. Fixel-based analysis is effective in studying white matter tractography and fiber changes in HD.
ISSN: 1662-4548
DOI: 10.3389/fnins.2021.711651
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2021 Oh, Chen, Wu, Valdes Hernandez, Tsai, Cheng, Chen, Wu, Lin and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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