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Title: Mixed-charge pseudo-zwitterionic copolymer brush as broad spectrum antibiofilm coating
Authors: Wu, Yang
Raju, Cheerlavancha
Hou, Zheng
Si, Zhangyong
Xu, Chen
Pranantyo, Dicky
Marimuthu, Kalisvar
De, Partha Pratim
Ng, Oon Tek
Pethe, Kevin
Kang, En-Tang
Chan-Park, Mary B.
Keywords: Engineering::Chemical engineering::Polymers and polymer manufacture
Issue Date: 2021
Source: Wu, Y., Raju, C., Hou, Z., Si, Z., Xu, C., Pranantyo, D., Marimuthu, K., De, P. P., Ng, O. T., Pethe, K., Kang, E. & Chan-Park, M. B. (2021). Mixed-charge pseudo-zwitterionic copolymer brush as broad spectrum antibiofilm coating. Biomaterials, 273, 120794-.
Project: MOE2013-T3-1-004
Journal: Biomaterials
Abstract: Zwitterionic polymers are classical antifouling polymers but they require specialized monomers that have cationic and anionic charges integrated into a single monomer. Herein, we show that pseudo-zwitterionic copolymers synthesized from a mixture of 2 monomers each having a single opposite polarity has excellent antibiofilm efficacy. We have discovered a new mixed-charge copolymer brush (#1-A) synthesized from 2 oppositely charged monomers, the anionic SPM (3-Sulfopropyl methacrylate) and the cationic AMPTMA ((3-Acrylamidopropyl) trimethylammonium chloride), that achieves broad spectrum in vitro antibiofilm effect of greater than 99% reductions against all six Gram-positive and Gram-negative bacteria tested. In the murine subcutaneous wound catheter infection models, the #1-A has good long-term anti-biofilm efficacy against MRSA and Pseudomonas aeruginosa of 3.41 and 3.19 orders respectively, outperforming previous mixed-charge copolymer coatings. We discovered a new method to choose the cationic/anionic pair combination to form the best antibiofilm copolymer brush coating by exploiting the solution polymerization kinetics disparity between the cationic and anionic monomers. We also showed that #1-A is softer and has higher hydration than the classical zwitterionic polymer. This study shows the possibility of achieving potent antibiofilm efficacy by combining readily available opposite singly charged monomers.
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2021.120794
Schools: School of Chemical and Biomedical Engineering 
School of Physical and Mathematical Sciences 
Lee Kong Chian School of Medicine (LKCMedicine) 
Research Centres: Centre for Antimicrobial Bioengineering 
Rights: © 2021 Elsevier Ltd. All rights reserved. This paper was published in Biomaterials and is made available with permission of Elsevier Ltd.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles
SCBE Journal Articles
SPMS Journal Articles

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