Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/154046
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dc.contributor.authorKallab, Martinen_US
dc.contributor.authorHommer, Nikolausen_US
dc.contributor.authorSchlatter, Andreasen_US
dc.contributor.authorBsteh, Gabrielen_US
dc.contributor.authorAltmann, Patricken_US
dc.contributor.authorPopa-Cherecheanu, Alinaen_US
dc.contributor.authorPfister, Martinen_US
dc.contributor.authorWerkmeister, René M.en_US
dc.contributor.authorSchmidl, Doreenen_US
dc.contributor.authorSchmetterer, Leopolden_US
dc.contributor.authorGarhöfer, Gerharden_US
dc.date.accessioned2022-06-08T02:00:27Z-
dc.date.available2022-06-08T02:00:27Z-
dc.date.issued2021-
dc.identifier.citationKallab, M., Hommer, N., Schlatter, A., Bsteh, G., Altmann, P., Popa-Cherecheanu, A., Pfister, M., Werkmeister, R. M., Schmidl, D., Schmetterer, L. & Garhöfer, G. (2021). Retinal oxygen metabolism and haemodynamics in patients with multiple sclerosis and history of optic neuritis. Frontiers in Neuroscience, 15, 761654-. https://dx.doi.org/10.3389/fnins.2021.761654en_US
dc.identifier.issn1662-4548en_US
dc.identifier.urihttps://hdl.handle.net/10356/154046-
dc.description.abstractVascular changes and alterations of oxygen metabolism are suggested to be implicated in multiple sclerosis (MS) pathogenesis and progression. Recently developed in vivo retinal fundus imaging technologies provide now an opportunity to non-invasively assess metabolic changes in the neural retina. This study was performed to assess retinal oxygen metabolism, peripapillary capillary density (CD), large vessel density (LVD), retinal nerve fiber layer thickness (RNFLT) and ganglion cell inner plexiform layer thickness (GCIPLT) in patients with diagnosed relapsing multiple sclerosis (RMS) and history of unilateral optic neuritis (ON). 16 RMS patients and 18 healthy controls (HC) were included in this study. Retinal oxygen extraction was modeled using O2 saturations and Doppler optical coherence tomography (DOCT) derived retinal blood flow (RBF) data. CD and LVD were assessed using optical coherence tomography (OCT) angiography. RNFLT and GCIPLT were measured using structural OCT. Measurements were performed in eyes with (MS+ON) and without (MS-ON) history for ON in RMS patients and in one eye in HC. Total oxygen extraction was lowest in MS+ON (1.8 ± 0.2 μl O2/min), higher in MS-ON (2.1 ± 0.5 μl O2/min, p = 0.019 vs. MS+ON) and highest in HC eyes (2.3 ± 0.6 μl O2/min, p = 0.002 vs. MS, ANOVA p = 0.031). RBF was lower in MS+ON (33.2 ± 6.0 μl/min) compared to MS-ON (38.3 ± 4.6 μl/min, p = 0.005 vs. MS+ON) and HC eyes (37.2 ± 4.7 μl/min, p = 0.014 vs. MS+ON, ANOVA p = 0.010). CD, LVD, RNFLT and GCIPL were significantly lower in MS+ON eyes. The present data suggest that structural alterations in the retina of RMS patients are accompanied by changes in oxygen metabolism, which are more pronounced in MS+ON than in MS-ON eyes. Whether these alterations promote MS onset and progression or occur as consequence of disease warrants further investigation. Clinical Trial Registration: ClinicalTrials.gov registry, NCT03401879.en_US
dc.language.isoenen_US
dc.relation.ispartofFrontiers in Neuroscienceen_US
dc.rights© 2021 Kallab, Hommer, Schlatter, Bsteh, Altmann, Popa-Cherecheanu, Pfister, Werkmeister, Schmidl, Schmetterer and Garhöfer. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.subjectScience::Medicineen_US
dc.titleRetinal oxygen metabolism and haemodynamics in patients with multiple sclerosis and history of optic neuritisen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.contributor.organizationSingapore Eye Research Instituteen_US
dc.contributor.organizationDuke-NUS Medical Schoolen_US
dc.contributor.researchSERI-NTU Advanced Ocular Engineering (STANCE)en_US
dc.identifier.doi10.3389/fnins.2021.761654-
dc.description.versionPublished versionen_US
dc.identifier.pmid34712117-
dc.identifier.scopus2-s2.0-85117882028-
dc.identifier.volume15en_US
dc.identifier.spage761654en_US
dc.subject.keywordsMultiple Sclerosisen_US
dc.subject.keywordsRetinal Blood Flowen_US
dc.description.acknowledgementSupport by the Austrian Science Fund (grant numbers KLI 721 and KLI 529) is gratefully acknowledged.en_US
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