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Title: DNA-derived nanostructures selectively capture gram-positive bacteria
Authors: Kim, Chan-Jin
Si, Zhangyong
Reghu, Sheethal
Guo, Zhong
Zhang, Kaixi
Li, Jianghua
Chan-Park, Mary B.
Keywords: Engineering::Chemical engineering::Polymers and polymer manufacture
Issue Date: 2021
Source: Kim, C., Si, Z., Reghu, S., Guo, Z., Zhang, K., Li, J. & Chan-Park, M. B. (2021). DNA-derived nanostructures selectively capture gram-positive bacteria. Drug Delivery and Translational Research, 11, 1438-1450.
Project: A1786a0032
Journal: Drug Delivery and Translational Research
Abstract: We report the first demonstration of the efficient bacteria targeting properties of DNA-based polymeric micelles with high-density DNA corona. Nanoscale polymer micelles derived from DNA-b-polystyrene (DNA-b-PS) efficiently selected most tested Gram-positive strains over Gram-negative strains; single-strand DNAs were 20-fold less selective. We demonstrate that these targeting properties were derived from the interaction between densely packed DNA strands of the micelle corona and the peptidoglycan layers of Gram-positive bacteria. DNA-b-PS micelles incorporating magnetic nanoparticles (MNPs) can efficiently capture and concentrate Gram-positive bacteria suggesting the simple applications of these DNA block copolymer micelles for concentrating bacteria. Adenine (A), thymine (T), cytosine (C), and guanine (G)-rich nanostructures were fabricated, respectively, for investigating the effect of sequence on Gram-selective bacteria targeting. T-rich micelles showed the most efficient targeting properties. The targeting properties of these DNA nanostructures toward Gram-positive bacteria may have applications as a targeted therapeutic delivery system.
ISSN: 2190-393X
DOI: 10.1007/s13346-021-00975-w
Rights: © 2021 Controlled Release Society. All rights reserved. This paper was published by Springer in Drug Delivery and Translational Research and is made available with permission of Controlled Release Society.
Fulltext Permission: embargo_20220907
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles
SCBE Journal Articles
SPMS Journal Articles

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