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Title: Late-life depressive symptomatology, motoric cognitive risk syndrome, and incident dementia: the "Nuage" study results
Authors: Beauchet, Olivier
Sekhon, Harmehr
Launay, Cyrille P.
Gaudreau, Pierrette
Morais, José A.
Allali, Gilles
Keywords: Science::Medicine
Issue Date: 2021
Source: Beauchet, O., Sekhon, H., Launay, C. P., Gaudreau, P., Morais, J. A. & Allali, G. (2021). Late-life depressive symptomatology, motoric cognitive risk syndrome, and incident dementia: the "Nuage" study results. Frontiers in Aging Neuroscience, 13, 740181-.
Journal: Frontiers in Aging Neuroscience
Abstract: Background: Late-life depressive symptomatology and motoric cognitive risk syndrome (MCR) have independently been associated with an increased risk for incident dementia. This study aimed to examine the association of late-life depressive symptomatology, MCR, and their combination on incident dementia in community-dwelling older adults living in Quebec (Canada). Methods: The study was carried out in a subset of 1,098 community dwellers aged ≥65 years recruited in the "Nutrition as a determinant of successful aging: The Quebec longitudinal study" (NuAge), an observational prospective cohort study with 3 years follow-up. At baseline, MCR was defined by the association of subjective cognitive complaint with slow walking speed, and late-life depressive symptomatology with a 30-item Geriatric Depression Scale (GDS) score >5/30. Incident dementia, defined as a Modified Mini-Mental State score ≤79/100 test and Instrumental Activity Daily Living score <4/4, was assessed at each annual visit. Results: The prevalence of late-life depressive symptomatology only was 31.1%, of MCR only 1.8%, and the combination of late-life depressive symptomatology and MCR 2.4%. The combination of late-life depressive symptomatology and MCR at baseline was associated with significant overall incident dementia (odds ratio (OR) = 2.31 with P ≤ 0.001) but not for MCR only (OR = 3.75 with P = 0.186) or late-life depressive symptomatology only (OR = 1.29 with P = 0.276). Conclusions: The combination of late-life depressive symptomatology and MCR is associated with incident dementia in older community dwellers. The results suggested an interplay between late-life depressive symptomatology and MCR exposing them to an increased risk for dementia.
ISSN: 1663-4365
DOI: 10.3389/fnagi.2021.740181
Rights: © 2021 Beauchet, Sekhon, Launay, Gaudreau, Morais and Allali. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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