Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/154078
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dc.contributor.authorLiu, Danen_US
dc.contributor.authorLiang, Minen_US
dc.contributor.authorZhu, Lien_US
dc.contributor.authorZhou, Ting-Tingen_US
dc.contributor.authorWang, Yuen_US
dc.contributor.authorWang, Ruien_US
dc.contributor.authorWu, Fei-Feien_US
dc.contributor.authorGoh, Eyleen Lay Keowen_US
dc.contributor.authorChen, Tengen_US
dc.date.accessioned2022-06-08T05:34:33Z-
dc.date.available2022-06-08T05:34:33Z-
dc.date.issued2021-
dc.identifier.citationLiu, D., Liang, M., Zhu, L., Zhou, T., Wang, Y., Wang, R., Wu, F., Goh, E. L. K. & Chen, T. (2021). Potential ago2/miR-3068-5p cascades in the nucleus accumbens contribute to methamphetamine-induced locomotor sensitization of mice. Frontiers in Pharmacology, 12, 708034-. https://dx.doi.org/10.3389/fphar.2021.708034en_US
dc.identifier.issn1663-9812en_US
dc.identifier.urihttps://hdl.handle.net/10356/154078-
dc.description.abstractDysregulation of microRNA (miRNA) biogenesis is involved in drug addiction. Argonaute2 (Ago2), a specific splicing protein involved in the generation of miRNA, was found to be dysregulated in the nucleus accumbens (NAc) of methamphetamine (METH)-sensitized mice in our previous study. Here, we determined whether Ago2 in the NAc regulates METH sensitization in mice and identified Ago2-dependent miRNAs involved in this process. We found a gradual reduction in Ago2 expression in the NAc following repeated METH use. METH-induced hyperlocomotor activity in mice was strengthened by knocking down NAc neuronal levels of Ago2 but reduced by overexpressing Ago2 in NAc neurons. Surprisingly, miR-3068-5p was upregulated following overexpression of Ago2 and downregulated by silencing Ago2 in the NAc. Knocking down miR-3068-5p, serving as an Ago2-dependent miRNA, strengthened the METH sensitization responses in mice. These findings demonstrated that dysregulated Ago2 in neurons in the NAc is capable of regulating METH sensitization and suggested a potential role of Ago2-dependent miR-3068-5p in METH sensitization.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.language.isoenen_US
dc.relationMOE2017-T3-1-002en_US
dc.relation.ispartofFrontiers in Pharmacologyen_US
dc.rights© 2021 Liu, Liang, Zhu, Zhou, Wang, Wang, Wu, Goh and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.subjectScience::Medicineen_US
dc.titlePotential ago2/miR-3068-5p cascades in the nucleus accumbens contribute to methamphetamine-induced locomotor sensitization of miceen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.contributor.organizationNational Neuroscience Instituteen_US
dc.identifier.doi10.3389/fphar.2021.708034-
dc.description.versionPublished versionen_US
dc.identifier.pmid34483916-
dc.identifier.scopus2-s2.0-85114301652-
dc.identifier.volume12en_US
dc.identifier.spage708034en_US
dc.subject.keywordsLocomotor Sensitizationen_US
dc.subject.keywordsMethamphetamineen_US
dc.description.acknowledgementThis work was supported by grants from the National Natural Science Foundation of China given to TC (Grant no. 81772034) and LZ (Grant no. 81701870); the Natural Science Foundation of Shaanxi Province to LZ (2020JQ-081); the Ministry of Education (MOE) Tier 3 grant to EG (Grant no. MOE2017-T3-1-002).en_US
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