Please use this identifier to cite or link to this item:
Title: The impact of negative symptoms and neurocognition on functioning in MDD and schizophrenia
Authors: Quek, Yue Feng
Yang, Zixu
Dauwels, Justin
Lee, Jimmy
Keywords: Science::Medicine
Issue Date: 2021
Source: Quek, Y. F., Yang, Z., Dauwels, J. & Lee, J. (2021). The impact of negative symptoms and neurocognition on functioning in MDD and schizophrenia. Frontiers in Psychiatry, 12, 648108-.
Project: QoL/RRG2-16009
Journal: Frontiers in Psychiatry
Abstract: Introduction: Negative symptoms, neurocognitive deficits and functional impairment are prevalent in individuals with major depressive disorder (MDD) and schizophrenia (SCZ). However, unlike neurocognitive deficits, little is known about the role of negative symptoms toward functioning in individuals with MDD. On the other hand, both factors are well-studied in individuals with SCZ. Thus, this study aimed to examine the contributions of negative symptoms and neurocognitive impairments in functioning in individuals with MDD, compared to individuals with SCZ. Methods: Participants included 50 individuals with MDD, 49 individuals with SCZ and 49 healthy controls. The following measures were administered-Negative Symptom Assessment (NSA-16), Brief Assessment of Cognition in Schizophrenia (BACS), Patient Health Questionnaire (PHQ-9), and MIRECC-Global Assessment of Functioning (MIRECC-GAF) to evaluate negative symptoms, neurocognition, depressive symptoms, and functioning respectively. Results: Both MDD and SCZ groups had significantly more severe negative symptoms, depressive symptoms, and poorer functioning than healthy controls. Individuals with SCZ performed significantly poorer on the BACS than the other two groups. Both negative symptoms and neurocognition were significantly correlated with social and occupational functioning in SCZ. Motivation subdomain of the negative symptoms was significantly correlated with occupational functioning, while depressive symptoms correlated with functioning in MDD. Conclusion: Both negative symptoms and neurocognitive deficits appear to play differential roles on individual domains of functioning between MDD and SCZ. Future longitudinal studies with larger sample sizes should be done for a better understanding about the associations between the factors and functioning.
ISSN: 1664-0640
DOI: 10.3389/fpsyt.2021.648108
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
School of Electrical and Electronic Engineering 
Organisations: Institute of Mental Health
Rights: © 2021 Quek, Yang, Dauwels and Lee. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:EEE Journal Articles
LKCMedicine Journal Articles

Files in This Item:
File Description SizeFormat 
fpsyt-12-648108.pdf220.35 kBAdobe PDFThumbnail

Citations 50

Updated on May 25, 2023

Web of ScienceTM
Citations 50

Updated on May 25, 2023

Page view(s)

Updated on May 30, 2023


Updated on May 30, 2023

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.