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dc.contributor.authorDominguez, Jacquelineen_US
dc.contributor.authorDe Guzman, Ma Feen_US
dc.contributor.authorChen, Annabel Shen-Hsingen_US
dc.contributor.authorSano, Maryen_US
dc.contributor.authorWaldemar, Gunhilden_US
dc.contributor.authorPhung, Thien Kieu Thien_US
dc.identifier.citationDominguez, J., De Guzman, M. F., Chen, A. S., Sano, M., Waldemar, G. & Phung, T. K. T. (2021). Filipino multicomponent intervention to maintain cognitive performance in high-risk population (FINOMAIN): study protocol for a cluster randomized controlled trial. Frontiers in Neurology, 12, 685721-.
dc.description.abstractBackground: More than half of the people with dementia live in lower-middle income countries (LMIC), yet we lack research and evidence-based knowledge to guide health promotion and prevention strategies for cognitive decline. In the Philippines, the prevalence of mild cognitive impairment (MCI) and cardiovascular risk factors among older persons are high, making this population at high risk for developing dementia. This protocol describes a cluster randomized controlled trial that aims to investigate the efficacy of a multicomponent intervention to maintain cognitive performance among high-risk population. Methods: This is a cluster-randomized, two-arm, single-blind trial of a multicomponent intervention that combines dance called INDAK (Improving Neurocognition through Dance and Kinesthetics), nutrition counseling, and vascular risk management. The intervention arm will receive 12 months (1-h, twice per week) of INDAK and every 3 months of nutrition counseling and intensive vascular risk management and monitoring. The control group will receive the usual vascular care advice and referral. A total of 605 (20-25 clusters per arm) community-dwelling Filipino older adults aged ≥ 60 years old with MCI will participate in the study and will be assessed at baseline, 6th- and 12th-month follow-up. The primary outcome is cognitive performance assessed by the Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog), Mnemonic Similarity Tasks (MST), and executive function composite (EFC). Secondary outcomes are functional connectivity assessed through brain imaging, and measures of behavioral, functional level, and quality of life. Discussion: The study aims to provide scientific evidence on a public health intervention that is contextualized in a community setting to reduce dementia risk among older adults with MCI. This model can be an ecological, low-cost, and effective program, thereby conducive to widespread implementation in the Philippines as well as in other low-resource settings with similar public health challenges. The pilot phase was underway with eight villages (clusters), but temporarily interrupted by the pandemic. The full study is anticipated to start after community restrictions are eased.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.relation.ispartofFrontiers in Neurologyen_US
dc.rights© 2021 Dominguez, de Guzman, Chen, Sano, Waldemar and Phung. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.subjectSocial sciences::Psychologyen_US
dc.titleFilipino multicomponent intervention to maintain cognitive performance in high-risk population (FINOMAIN): study protocol for a cluster randomized controlled trialen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Social Sciencesen_US
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.contributor.researchCenter of Research and Development in Learningen_US
dc.description.versionPublished versionen_US
dc.subject.keywordsMild Cognitive Impairmenten_US
dc.subject.keywordsCluster-Randomized Trialen_US
dc.description.acknowledgementThis study was supported by grants from the Philippine Institute for Traditional and Alternative Health Care (PITHAC) of the Department of Health. The contributions of SC are partly supported by the Ministry of Education, Singapore, Academic Research Fund (MOE2019-T2-1-019).en_US
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