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Title: Differential cytokine responses in hospitalized COVID-19 patients limit efficacy of Remdesivir
Authors: Chan, Yi-Hao
Young, Barnaby Edward
Fong, Siew-Wai
Ding, Ying
Goh, Yun Shan
Chee, Rhonda Sin-Ling
Tan, Seow-Yen
Kalimuddin, Shirin
Tambyah, Paul A.
Leo, Yee Sin
Ng, Lisa F. P.
Lye, David C.
Renia, Laurent
Keywords: Science::Medicine
Issue Date: 2021
Source: Chan, Y., Young, B. E., Fong, S., Ding, Y., Goh, Y. S., Chee, R. S., Tan, S., Kalimuddin, S., Tambyah, P. A., Leo, Y. S., Ng, L. F. P., Lye, D. C. & Renia, L. (2021). Differential cytokine responses in hospitalized COVID-19 patients limit efficacy of Remdesivir. Frontiers in Immunology, 12, 680188-.
Project: H/20/04/g1/006 
IAF 311006 
H16/99/ b0/011 
Journal: Frontiers in Immunology 
Abstract: A significant proportion of COVID-19 patients will progress to critical illness requiring invasive mechanical ventilation. This accentuates the need for a therapy that can reduce the severity of COVID-19. Clinical trials have shown the effectiveness of remdesivir in shortening recovery time and decreasing progression to respiratory failure and mechanical ventilation. However, some studies have highlighted its lack of efficacy in patients on high-flow oxygen and mechanical ventilation. This study uncovers some underlying immune response differences between responders and non-responders to remdesivir treatment. Immunological analyses revealed an upregulation of tissue repair factors BDNF, PDGF-BB and PIGF-1, as well as an increase in ratio of Th2-associated cytokine IL-4 to Th1-associated cytokine IFN-γ. Serological profiling of IgG subclasses corroborated this observation, with significantly higher magnitude of increase in Th2-associated IgG2 and IgG4 responses. These findings help to identify the mechanisms of immune regulation accompanying successful remdesivir treatment in severe COVID-19 patients.
ISSN: 1664-3224
DOI: 10.3389/fimmu.2021.680188
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Organisations: National Centre for Infectious Diseases, Singapore
Tan Tock Seng Hospital
National University of Singapore
National University Health System
Rights: © 2021 Chan, Young, Fong, Ding, Goh, Chee, Tan, Kalimuddin, Tambyah, Leo, Ng, Lye and Renia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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