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Title: A multiplex thyroid-specific assay for quantification of circulating thyroid cell-free RNA in plasma of thyroid cancer patients
Authors: Yang, Samantha Peiling
Koh, Winston Lian Chye
Kong, Kiat Whye
Parameswaran, Rajeev
Loke, Kelvin Siu Hoong
Ngiam, Kee Yuan
Tan, Wee Boon
Loh, Thomas
Ng, David Chee Eng
Goh, Boon Cher
Ngeow, Joanne
Tai, E. Shyong
Keywords: Science::Medicine
Issue Date: 2021
Source: Yang, S. P., Koh, W. L. C., Kong, K. W., Parameswaran, R., Loke, K. S. H., Ngiam, K. Y., Tan, W. B., Loh, T., Ng, D. C. E., Goh, B. C., Ngeow, J. & Tai, E. S. (2021). A multiplex thyroid-specific assay for quantification of circulating thyroid cell-free RNA in plasma of thyroid cancer patients. Frontiers in Genetics, 12, 721832-.
Journal: Frontiers in Genetics
Abstract: The standard of care for thyroid cancer management is thyroidectomy and adjuvant radioactive iodine (RAI). There is a paucity of clinical tool that quantifies residual thyroid volume reliably for precise adjuvant RAI dosing. Serum thyroglobulin (TG), tumour marker for thyroid cancer, takes 4 weeks for complete clearance due to its long half-life, and might be undetectable in 12% of structural disease patients. It detects recurrence with a sensitivity of 19-40%, mainly attributed to issue of TG antibody interference with TG immunometric assay. We hypothesise that the quantity of thyroid-specific cell-free RNA (cfRNA) is indicative of amount of thyroid tissues, and that during thyroid surgery, cfRNA levels decrease accordingly.
ISSN: 1664-8021
DOI: 10.3389/fgene.2021.721832
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Organisations: National Cancer Centre
Rights: © 2021 Yang, Koh, Kong, Parameswaran, Loke, Ngiam, Tan, Loh, Ng, Goh, Ngeow and Tai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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