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https://hdl.handle.net/10356/154183| Title: | A multiplex thyroid-specific assay for quantification of circulating thyroid cell-free RNA in plasma of thyroid cancer patients | Authors: | Yang, Samantha Peiling Koh, Winston Lian Chye Kong, Kiat Whye Parameswaran, Rajeev Loke, Kelvin Siu Hoong Ngiam, Kee Yuan Tan, Wee Boon Loh, Thomas Ng, David Chee Eng Goh, Boon Cher Ngeow, Joanne Tai, E. Shyong |
Keywords: | Science::Medicine | Issue Date: | 2021 | Source: | Yang, S. P., Koh, W. L. C., Kong, K. W., Parameswaran, R., Loke, K. S. H., Ngiam, K. Y., Tan, W. B., Loh, T., Ng, D. C. E., Goh, B. C., Ngeow, J. & Tai, E. S. (2021). A multiplex thyroid-specific assay for quantification of circulating thyroid cell-free RNA in plasma of thyroid cancer patients. Frontiers in Genetics, 12, 721832-. https://dx.doi.org/10.3389/fgene.2021.721832 | Journal: | Frontiers in Genetics | Abstract: | The standard of care for thyroid cancer management is thyroidectomy and adjuvant radioactive iodine (RAI). There is a paucity of clinical tool that quantifies residual thyroid volume reliably for precise adjuvant RAI dosing. Serum thyroglobulin (TG), tumour marker for thyroid cancer, takes 4 weeks for complete clearance due to its long half-life, and might be undetectable in 12% of structural disease patients. It detects recurrence with a sensitivity of 19-40%, mainly attributed to issue of TG antibody interference with TG immunometric assay. We hypothesise that the quantity of thyroid-specific cell-free RNA (cfRNA) is indicative of amount of thyroid tissues, and that during thyroid surgery, cfRNA levels decrease accordingly. | URI: | https://hdl.handle.net/10356/154183 | ISSN: | 1664-8021 | DOI: | 10.3389/fgene.2021.721832 | Schools: | Lee Kong Chian School of Medicine (LKCMedicine) | Organisations: | National Cancer Centre | Rights: | © 2021 Yang, Koh, Kong, Parameswaran, Loke, Ngiam, Tan, Loh, Ng, Goh, Ngeow and Tai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
| Appears in Collections: | LKCMedicine Journal Articles |
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|---|---|---|---|---|
| fgene-12-721832.pdf | 3.5 MB | Adobe PDF |  View/Open |
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