Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/154233
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dc.contributor.authorLuchetti, Alessandroen_US
dc.contributor.authorYamaguchi, Takumaen_US
dc.contributor.authorUemura, Masatoen_US
dc.contributor.authorYovianto, Glenen_US
dc.contributor.authorČulig, Lukaen_US
dc.contributor.authorYang, Mingen_US
dc.contributor.authorZhou, Weien_US
dc.contributor.authorOschmann, Franziskaen_US
dc.contributor.authorLua, MinFengen_US
dc.contributor.authorTashiro, Ayumuen_US
dc.date.accessioned2021-12-19T08:34:28Z-
dc.date.available2021-12-19T08:34:28Z-
dc.date.issued2021-
dc.identifier.citationLuchetti, A., Yamaguchi, T., Uemura, M., Yovianto, G., Čulig, L., Yang, M., Zhou, W., Oschmann, F., Lua, M. & Tashiro, A. (2021). Within-trial persistence of learned behavior as a dissociable behavioral component in hippocampus - dependent memory tasks : a potential postlearning role of immature neurons in the adult dentate gyrus. ENeuro, 8(4). https://dx.doi.org/10.1523/ENEURO.0195-21.2021en_US
dc.identifier.issn2373-2822en_US
dc.identifier.urihttps://hdl.handle.net/10356/154233-
dc.description.abstractThe term "memory strength" generally refers to how well one remembers something. But more precisely it contains multiple modalities, such as how easily, how accurately, how confidently and how vividly we remember it. In human, these modalities of memory strength are dissociable. In this study, we asked whether we can isolate a behavioral component that is dissociable from others in hippocampus-dependent memory tasks in mice, which potentially reflect a modality of memory strength. Using a virus-mediated inducible method, we ablated immature neurons in the dentate gyrus in mice after we trained the mice with hippocampus-dependent memory tasks normally. In memory retrieval tests, these ablated mice initially showed intact performance. However, the ablated mice ceased learned behavior prematurely within a trial compared with control mice. In addition, the ablated mice showed shorter duration of individual episodes of learned behavior. Both affected behavioral measurements point to persistence of learned behavior. Thus, the effect of the postlearning manipulation showed dissociation between initial performance and persistence of learned behavior. These two behavioral components are likely to reflect different brain functions and be mediated by separate mechanisms, which might represent different modalities of memory strength. These simple dissociable measurements in widely used behavioral paradigms would be useful to understand detailed mechanisms underlying the expression of learned behavior and potentially different modalities of memory strength in mice. We also discuss a potential role that immature neurons in the dentate gyrus may play in persistence of learned behavior.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.description.sponsorshipNational Medical Research Council (NMRC)en_US
dc.language.isoenen_US
dc.relation2018- T1-002-053en_US
dc.relationMOE2015-T2-2-035en_US
dc.relationMOE2017-T3-1-002en_US
dc.relationNMRC/ OFIRG/0046/2017en_US
dc.relation.ispartofeNeuroen_US
dc.rights© 2021 Luchetti et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.en_US
dc.subjectScience::Biological sciencesen_US
dc.titleWithin-trial persistence of learned behavior as a dissociable behavioral component in hippocampus - dependent memory tasks : a potential postlearning role of immature neurons in the adult dentate gyrusen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.identifier.doi10.1523/ENEURO.0195-21.2021-
dc.description.versionPublished versionen_US
dc.identifier.pmid34281981-
dc.identifier.scopus2-s2.0-85112128306-
dc.identifier.issue4en_US
dc.identifier.volume8en_US
dc.subject.keywordsAdult Neurogenesisen_US
dc.subject.keywordsFear Conditioningen_US
dc.description.acknowledgementThis work was supported by Ministry of Education, Singapore, Grants 2018- T1-002-053, MOE2015-T2-2-035, and MOE2017-T3-1-002; the National Medical Research Council, Ministry of Health, Singapore, Grant NMRC/ OFIRG/0046/2017; the European Research Council Gant 208132; the James S. McDonnell Foundation (A.T.); and a Human Frontier Science Programme long-term fellowship (M.U.).en_US
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