Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/154233
Title: Within-trial persistence of learned behavior as a dissociable behavioral component in hippocampus - dependent memory tasks : a potential postlearning role of immature neurons in the adult dentate gyrus
Authors: Luchetti, Alessandro
Yamaguchi, Takuma
Uemura, Masato
Yovianto, Glen
Čulig, Luka
Yang, Ming
Zhou, Wei
Oschmann, Franziska
Lua, MinFeng
Tashiro, Ayumu
Keywords: Science::Biological sciences
Issue Date: 2021
Source: Luchetti, A., Yamaguchi, T., Uemura, M., Yovianto, G., Čulig, L., Yang, M., Zhou, W., Oschmann, F., Lua, M. & Tashiro, A. (2021). Within-trial persistence of learned behavior as a dissociable behavioral component in hippocampus - dependent memory tasks : a potential postlearning role of immature neurons in the adult dentate gyrus. ENeuro, 8(4). https://dx.doi.org/10.1523/ENEURO.0195-21.2021
Project: 2018- T1-002-053
MOE2015-T2-2-035 
MOE2017-T3-1-002 
NMRC/ OFIRG/0046/2017 
Journal: eNeuro
Abstract: The term "memory strength" generally refers to how well one remembers something. But more precisely it contains multiple modalities, such as how easily, how accurately, how confidently and how vividly we remember it. In human, these modalities of memory strength are dissociable. In this study, we asked whether we can isolate a behavioral component that is dissociable from others in hippocampus-dependent memory tasks in mice, which potentially reflect a modality of memory strength. Using a virus-mediated inducible method, we ablated immature neurons in the dentate gyrus in mice after we trained the mice with hippocampus-dependent memory tasks normally. In memory retrieval tests, these ablated mice initially showed intact performance. However, the ablated mice ceased learned behavior prematurely within a trial compared with control mice. In addition, the ablated mice showed shorter duration of individual episodes of learned behavior. Both affected behavioral measurements point to persistence of learned behavior. Thus, the effect of the postlearning manipulation showed dissociation between initial performance and persistence of learned behavior. These two behavioral components are likely to reflect different brain functions and be mediated by separate mechanisms, which might represent different modalities of memory strength. These simple dissociable measurements in widely used behavioral paradigms would be useful to understand detailed mechanisms underlying the expression of learned behavior and potentially different modalities of memory strength in mice. We also discuss a potential role that immature neurons in the dentate gyrus may play in persistence of learned behavior.
URI: https://hdl.handle.net/10356/154233
ISSN: 2373-2822
DOI: 10.1523/ENEURO.0195-21.2021
Rights: © 2021 Luchetti et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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