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Title: Role of NMDA receptors in adult neurogenesis and normal development of the dentate gyrus
Authors: Åmellem, Ingrid
Yovianto, Glen
Chong, Hai Tarng
Nair, Rajeevkumar Raveendran
Cnops, Vanja
Thanawalla, Ayesha
Tashiro, Ayumu
Keywords: Science::Biological sciences
Issue Date: 2021
Source: Åmellem, I., Yovianto, G., Chong, H. T., Nair, R. R., Cnops, V., Thanawalla, A. & Tashiro, A. (2021). Role of NMDA receptors in adult neurogenesis and normal development of the dentate gyrus. ENeuro, 8(4), ENEURO.0566-20.2021-.
Project: 2016-T1-001–010 
Journal: eNeuro 
Abstract: The NMDA receptors are a type of glutamate receptors, which is involved in neuronal function, plasticity and development in the mammalian brain. However, how the NMDA receptors contribute to adult neurogenesis and development of the dentate gyrus is unclear. In this study, we investigate this question by examining a region-specific knock-out mouse line that lacks the NR1 gene, which encodes the essential subunit of the NMDA receptors, in granule cells of the dentate gyrus (DG-NR1KO mice). We found that the survival of newly-generated granule cells, cell proliferation and the size of the granule cell layer are significantly reduced in the dorsal dentate gyrus of adult DG-NR1KO mice. Our results also show a significant reduction in the number of immature neurons and in the volume of the granule cell layer, starting from three weeks of postnatal age. DG-NR1KO mice also showed impairment in the expression of an immediate early gene, Arc, and behavior during the novelty-suppressed feeding and open field test. These results suggest that the NMDA receptors in granule cells have a role in adult neurogenesis in the adult brain and contributes to the normal development of the dentate gyrus.
ISSN: 2373-2822
DOI: 10.1523/ENEURO.0566-20.2021
Schools: School of Biological Sciences 
Rights: © 2021 Åmellem et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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