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Title: A flexible multiplexed immunosensor for point-of-care in situ wound monitoring
Authors: Gao, Yuji
Nguyen, Dat T.
Yeo, Trifanny
Lim, Su Bin
Tan, Wei Xian
Madden, Leigh Edward
Jin, Lin
Long, Kenan Ji Yong
Fazila Abu Bakar Aloweni
Liew, Angela Yi Jia
Tan, Mandy Li Ling
Ang, Shin Yuh
Sivagame D/O Maniya
Ibrahim Abdelwahab
Loh, Kian Ping
Chen, Chia-Hung
Becker, David Laurence
Leavesley, David
Ho, John S.
Lim, Chwee Teck
Keywords: Science::Medicine
Issue Date: 2021
Source: Gao, Y., Nguyen, D. T., Yeo, T., Lim, S. B., Tan, W. X., Madden, L. E., Jin, L., Long, K. J. Y., Fazila Abu Bakar Aloweni, Liew, A. Y. J., Tan, M. L. L., Ang, S. Y., Sivagame D/O Maniya, Ibrahim Abdelwahab, Loh, K. P., Chen, C., Becker, D. L., Leavesley, D., Ho, J. S. & Lim, C. T. (2021). A flexible multiplexed immunosensor for point-of-care in situ wound monitoring. Science Advances, 7(21), eabg9614-.
Journal: Science Advances 
Abstract: Chronic wounds arise from interruption of normal healing due to many potential pathophysiological factors. Monitoring these multivariate factors can provide personalized diagnostic information for wound management, but current sensing technologies use complex laboratory tests or track a limited number of wound parameters. We report a flexible biosensing platform for multiplexed profiling of the wound microenvironment, inflammation, and infection state at the point of care. This platform integrates a sensor array for measuring inflammatory mediators [tumor necrosis factor-α, interleukin-6 (IL-6), IL-8, and transforming growth factor-β1], microbial burden (Staphylococcus aureus), and physicochemical parameters (temperature and pH) with a microfluidic wound exudate collector and flexible electronics for wireless, smartphone-based data readout. We demonstrate in situ multiplexed monitoring in a mouse wound model and also profile wound exudates from patients with venous leg ulcers. This technology may facilitate more timely and personalized wound management to improve chronic wound healing outcomes.
ISSN: 2375-2548
DOI: 10.1126/sciadv.abg9614
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Organisations: Skin Research Institute of Singapore, A*STAR
Rights: © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S.Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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