Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/154384
Title: Polymers as advanced antibacterial and antibiofilm agents for direct and combination therapies
Authors: Si, Zhangyong
Zheng, Wenbin
Prananty, Dicky
Li, Jianghua
Koh, Chong Hui
Kang, En-Tang
Pethe, Kevin
Chan-Park, Mary B.
Keywords: Engineering::Chemical engineering::Polymers and polymer manufacture
Issue Date: 2022
Source: Si, Z., Zheng, W., Prananty, D., Li, J., Koh, C. H., Kang, E., Pethe, K. & Chan-Park, M. B. (2022). Polymers as advanced antibacterial and antibiofilm agents for direct and combination therapies. Chemical Science. https://dx.doi.org/10.1039/D1SC05835E
Project: MOE2018-T3-1-003
Journal: Chemical Science
Abstract: The growing prevalence of antimicrobial drug resistance in pathogenic bacteria is a critical threat to global health. Conventional antibiotics still play a crucial role in treating bacterial infections, but the emergence and spread of antibiotic-resistant micro-organisms are rapidly eroding their usefulness. Cationic polymers, which target bacterial membranes, are thought to be the last frontier in antibacterial development. This class of molecules possesses several advantages including a low propensity for emergence of resistance and rapid bactericidal effect. This review surveys the structure-activity of advanced antimicrobial cationic polymers, including poly(α-amino acids), β-peptides, polycarbonates, star polymers and main-chain cationic polymers, with low toxicity and high selectivity to potentially become useful for real applications. Their uses as potentiating adjuvants to overcome bacterial membrane-related resistance mechanisms and as antibiofilm agents are also covered. The review is intended to provide valuable information for design and development of cationic polymers as antimicrobial and antibiofilm agents for translational applications.
URI: https://hdl.handle.net/10356/154384
ISSN: 2041-6520
DOI: 10.1039/D1SC05835E
Rights: © 2021 The Author(s). Published by the Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported LIcense.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles
SBS Journal Articles
SCBE Journal Articles
SPMS Journal Articles

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