Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/154592
Title: Clarifying the in-situ cytotoxic potential of electronic waste plastics
Authors: Shi, Pujiang
Wan, Yan
Grandjean, Agnès
Lee, Jong-Min
Tay, Chor Yong
Keywords: Engineering::Materials
Engineering::Chemical engineering
Science::Biological sciences
Issue Date: 2021
Source: Shi, P., Wan, Y., Grandjean, A., Lee, J. & Tay, C. Y. (2021). Clarifying the in-situ cytotoxic potential of electronic waste plastics. Chemosphere, 269, 128719-. https://dx.doi.org/10.1016/j.chemosphere.2020.128719
Project: USS-IF-2018-4
Journal: Chemosphere
Abstract: Plastics in waste electronics (E-plastics) account for approximately 20% of the entire global electronic waste (E-waste) stream. Most of the E-plastics are not recycled as the presence of toxic additives (e.g. heavy metals, brominated flame retardants (BFRs), antimony, etc.) have associated environmental and health concerns. However, the majority of the studies are focused on quantitative assessment of the toxic constituents in E-plastics, while empirical information regarding the potential toxic effects in humans is largely lacking. To gain a deeper appreciation into the toxicological profile of E-plastics, in situ time-dependent exposures of 6 different human cell lines to a panel of 8 representative E-plastics recovered from liquid crystal displays (LCD), keyboards, screen frames, and wire insulators were conducted. Although several hazardous elements (e.g. Pb, As, Sb, Zn, Cu, etc) were detected at concentrations that far exceed the limit values permitted by the Restriction of Hazardous Substances Directive and EU Directives in the panel E-plastics, in-depth analysis of the 144 unique cell viability data points and live-dead staining experiments suggest that the acute and sub-chronic toxic effects of E-plastics in direct contact with human cells are negligible. These observations agreed with the inductively coupled plasma-optical emission spectrometry data, which revealed that leaching of these toxic additives into the biological milieu is not sufficiently high to trigger a cytotoxic response up to a continuous culture period of 2 weeks. The novel insights gained from this study are posited to further clarify the uncertainty associated with the safety and circular economy implementation of E-plastics.
URI: https://hdl.handle.net/10356/154592
ISSN: 0045-6535
DOI: 10.1016/j.chemosphere.2020.128719
Rights: © 2020 Elsevier Ltd. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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