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Title: Mesoporous polydopamine with built-in plasmonic core: Traceable and NIR triggered delivery of functional proteins
Authors: Wu, Di
Zhou, Jiajing
Chen, Xiaohong
Chen, Yonghao
Hou, Shuai
Qian, Hehe
Zhang, Lifeng
Tang, Guping
Chen, Zhong
Ping, Yuan
Fang, Wenjun
Duan, Hongwei
Keywords: Engineering::Chemical engineering
Issue Date: 2020
Source: Wu, D., Zhou, J., Chen, X., Chen, Y., Hou, S., Qian, H., Zhang, L., Tang, G., Chen, Z., Ping, Y., Fang, W. & Duan, H. (2020). Mesoporous polydopamine with built-in plasmonic core: Traceable and NIR triggered delivery of functional proteins. Biomaterials, 238, 119847-.
Project: M0E2015-T2-1-112
Journal: Biomaterials
Abstract: Functional proteins are essential for the regulation of cellular behaviors and have found growing therapeutic uses. However, low bioavailability of active proteins to their intracellular targets has been a long-standing challenge to achieve their full potential for cell reprogramming and disease treatment. Here we report mesoporous polydopamine (mPDA) with a built-in plasmonic nanoparticle core as a multifunctional protein delivery system. The mPDA with a unique combination of large surface area, metal-chelating property, and broad-spectrum photothermal transduction allows efficient loading and near-infrared light-triggered release of functional proteins, while the plasmonic core serves as a photostable tracer and fluorescence quencher, collectively leading to real-time monitoring and active cytosolic release of model proteins. In particular, controlled delivery of cytotoxic ribonuclease A has shown excellent performance in invivo cancer therapy. The possibility of coating mPDA on a broad range of functional cores, thanks to its universal adhesion, provides opportunities for developing tailored delivery carriers of biologics to overcome intrinsic biological barriers.
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2020.119847
Rights: © 2020 Published by Elsevier Ltd.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles

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