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|Title:||Mesoporous polydopamine with built-in plasmonic core: Traceable and NIR triggered delivery of functional proteins||Authors:||Wu, Di
|Keywords:||Engineering::Chemical engineering||Issue Date:||2020||Source:||Wu, D., Zhou, J., Chen, X., Chen, Y., Hou, S., Qian, H., Zhang, L., Tang, G., Chen, Z., Ping, Y., Fang, W. & Duan, H. (2020). Mesoporous polydopamine with built-in plasmonic core: Traceable and NIR triggered delivery of functional proteins. Biomaterials, 238, 119847-. https://dx.doi.org/10.1016/j.biomaterials.2020.119847||Project:||M0E2015-T2-1-112
|Journal:||Biomaterials||Abstract:||Functional proteins are essential for the regulation of cellular behaviors and have found growing therapeutic uses. However, low bioavailability of active proteins to their intracellular targets has been a long-standing challenge to achieve their full potential for cell reprogramming and disease treatment. Here we report mesoporous polydopamine (mPDA) with a built-in plasmonic nanoparticle core as a multifunctional protein delivery system. The mPDA with a unique combination of large surface area, metal-chelating property, and broad-spectrum photothermal transduction allows efficient loading and near-infrared light-triggered release of functional proteins, while the plasmonic core serves as a photostable tracer and fluorescence quencher, collectively leading to real-time monitoring and active cytosolic release of model proteins. In particular, controlled delivery of cytotoxic ribonuclease A has shown excellent performance in invivo cancer therapy. The possibility of coating mPDA on a broad range of functional cores, thanks to its universal adhesion, provides opportunities for developing tailored delivery carriers of biologics to overcome intrinsic biological barriers.||URI:||https://hdl.handle.net/10356/154795||ISSN:||0142-9612||DOI:||10.1016/j.biomaterials.2020.119847||Rights:||© 2020 Published by Elsevier Ltd.||Fulltext Permission:||none||Fulltext Availability:||No Fulltext|
|Appears in Collections:||SCBE Journal Articles|
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