Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/154824
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dc.contributor.authorJana, Deblinen_US
dc.contributor.authorWang, Dongdongen_US
dc.contributor.authorRajendran, Praveenbalajien_US
dc.contributor.authorBindra, Anivind Kauren_US
dc.contributor.authorGuo, Yien_US
dc.contributor.authorLiu, Jiaweien_US
dc.contributor.authorPramanik, Manojiten_US
dc.contributor.authorZhao, Yanlien_US
dc.date.accessioned2022-01-12T04:34:59Z-
dc.date.available2022-01-12T04:34:59Z-
dc.date.issued2021-
dc.identifier.citationJana, D., Wang, D., Rajendran, P., Bindra, A. K., Guo, Y., Liu, J., Pramanik, M. & Zhao, Y. (2021). Hybrid carbon dot assembly as a reactive oxygen species nanogenerator for ultrasound-assisted tumor ablation. JACS Au, 1(12), 2328-2338. https://dx.doi.org/10.1021/jacsau.1c00422en_US
dc.identifier.issn2691-3704en_US
dc.identifier.urihttps://hdl.handle.net/10356/154824-
dc.description.abstractThe efficacy of reactive oxygen species (ROS)-based therapy is substantially constrained by the limited ROS generation, stern activation conditions, and lack of a straightforward reaction paradigm. Carbon dots (CDs) have been highly sought after for therapeutic applications for their biocompatibility and intrinsic fluorescence imaging capabilities, making them suitable for ROS generation. Herein, we synthesized a CD-based ultrasmall hybrid nanostructure possessing active sites of Mo, Cu, and IR-780 dye. After cooperative self-assembly with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-poly(ethylene glycol), the obtained assembly (CMIR-CDa) exhibits near-infrared fluorescence imaging and photoacoustic tomography. Interestingly, CMIR-CDa can generate singlet oxygen (1O2), hydroxyl radical (·OH), and superoxide radical anion (O2 • -) upon ultrasound stimulus owing to its sonosensitizing and enzyme-mimicking properties, showing an enhanced efficacy for tumor ablation in vivo. The collective in vitro and in vivo results indicate that CMIR-CDa has a high potency as an ROS nanogenerator under US irradiation, even at a low concentration. The present study offers an approach for engineering hybrid CDs in a bioinspired way for intratumoral ROS augmentation in response to deep tissue penetrable external stimuli.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.description.sponsorshipNational Research Foundation (NRF)en_US
dc.language.isoenen_US
dc.relationA20E5c0081en_US
dc.relationNRF-NRFI2018-03en_US
dc.relation.ispartofJACS Auen_US
dc.rights© 2021 The Authors. Published by American Chemical Society. This is an open-access article distributed under the terms of the Creative Commons Attribution License.en_US
dc.subjectEngineering::Bioengineeringen_US
dc.titleHybrid carbon dot assembly as a reactive oxygen species nanogenerator for ultrasound-assisted tumor ablationen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doi10.1021/jacsau.1c00422-
dc.description.versionPublished versionen_US
dc.identifier.pmid34977901-
dc.identifier.issue12en_US
dc.identifier.volume1en_US
dc.identifier.spage2328en_US
dc.identifier.epage2338en_US
dc.subject.keywordsChemodynamic Therapyen_US
dc.subject.keywordsHybrid Nanostructureen_US
dc.description.acknowledgementThis research was supported by the Singapore Agency for Science, Technology and Research (A*STAR) AME IRG grant (A20E5c0081) and the Singapore National Research Foundation Investigatorship (NRF-NRFI2018-03).en_US
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