Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/154826
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dc.contributor.authorPang, Jia Haoen_US
dc.contributor.authorOng, Derek Yirenen_US
dc.contributor.authorChiba, Shunsukeen_US
dc.date.accessioned2022-01-12T07:31:52Z-
dc.date.available2022-01-12T07:31:52Z-
dc.date.issued2021-
dc.identifier.citationPang, J. H., Ong, D. Y. & Chiba, S. (2021). C2 amination of pyridine with primary amines mediated by sodium hydride in the presence of lithium iodide. Organic Syntheses, 98, 363-373. https://dx.doi.org/10.15227/ORGSYN.098.0363en_US
dc.identifier.issn0078-6209en_US
dc.identifier.urihttps://hdl.handle.net/10356/154826-
dc.description.abstractN-Butylpyridin-2-amine (3). An oven-dried, 250 mL three-necked roundbottomed flask fitted with a 25 x 15 mm Teflon-coated oval magnetic stir bar, a thermometer, rubber septum and a Liebig reflux condenser, is connected to a Schlenk line (Note 2). Sodium hydride (NaH) (3.00 g, 75.0 mmol, 3.0 equiv) (Note 3) is charged to the reaction vessel, after which it is evacuated and backfilled with argon three times. Anhydrous THF (Note 4) (35 mL) is added via a syringe. The reaction flask is suspended in a 22 °C water bath, and lithium iodide (LiI) (6.69 g, 50.0 mmol, 2.0 equiv) (Note 5) is introduced through the top of the reflux condenser, after which the Ar line is reintroduced with an out needle in place for 5 min to exchange the atmosphere.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.description.sponsorshipNanyang Technological Universityen_US
dc.language.isoenen_US
dc.relationMOE2019-T2-1-089en_US
dc.relation.ispartofOrganic Synthesesen_US
dc.rights© 2021 Organic Syntheses, Inc. All rights reserved. This paper was published in Organic Syntheses and is made available with permission of Organic Syntheses, Inc.en_US
dc.subjectScience::Chemistryen_US
dc.titleC2 amination of pyridine with primary amines mediated by sodium hydride in the presence of lithium iodideen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doi10.15227/ORGSYN.098.0363-
dc.description.versionAccepted versionen_US
dc.identifier.scopus2-s2.0-85118797893-
dc.identifier.volume98en_US
dc.identifier.spage363en_US
dc.identifier.epage373en_US
dc.subject.keywordsAcridine Derivativeen_US
dc.subject.keywordsBenzyl Cyanideen_US
dc.description.acknowledgementThis work was supported by Nanyang Technological University, the Singapore Ministry of Education (Academic Research Fund Tier 2: MOE2019-T2-1-089).en_US
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