Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/154828
Title: Synthesis of α-alkynylnitrones via hydromagnesiation of 1,3-enynes with magnesium hydride
Authors: Li, Yihang
Ng, Jia Sheng
Wang, Bin
Chiba, Shunsuke
Keywords: Science::Chemistry
Issue Date: 2021
Source: Li, Y., Ng, J. S., Wang, B. & Chiba, S. (2021). Synthesis of α-alkynylnitrones via hydromagnesiation of 1,3-enynes with magnesium hydride. Organic Letters, 23(13), 5060-5064. https://dx.doi.org/10.1021/acs.orglett.1c01583
Project: MOE2019-T2-1-089
Journal: Organic Letters
Abstract: A protocol for the synthesis of α-alkynylnitrones from 1,3-enynes has been developed. The process is triggered by hydromagnesiation of 1,3-enynes with magnesium hydride (MgH2), which is prepared in situ through solvothermal treatment of magnesium iodide (MgI2) with sodium hydride (NaH) in tetrahydrofuran. Downstream functionalization of the resulting propargylmagnesium intermediates with organo nitro compounds affords α-alkynylnitrones, which could be used as versatile precursors for the construction of various nitrogen-containing compounds.
URI: https://hdl.handle.net/10356/154828
ISSN: 1523-7060
DOI: 10.1021/acs.orglett.1c01583
Schools: School of Physical and Mathematical Sciences 
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.1c01583.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

Files in This Item:
File Description SizeFormat 
Manuscript_Chiba_rev_deposit.pdf488.33 kBAdobe PDFThumbnail
View/Open

SCOPUSTM   
Citations 50

7
Updated on May 27, 2023

Web of ScienceTM
Citations 20

7
Updated on May 29, 2023

Page view(s)

43
Updated on May 31, 2023

Download(s)

13
Updated on May 31, 2023

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.