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https://hdl.handle.net/10356/154828| Title: | Synthesis of α-alkynylnitrones via hydromagnesiation of 1,3-enynes with magnesium hydride | Authors: | Li, Yihang Ng, Jia Sheng Wang, Bin Chiba, Shunsuke |
Keywords: | Science::Chemistry | Issue Date: | 2021 | Source: | Li, Y., Ng, J. S., Wang, B. & Chiba, S. (2021). Synthesis of α-alkynylnitrones via hydromagnesiation of 1,3-enynes with magnesium hydride. Organic Letters, 23(13), 5060-5064. https://dx.doi.org/10.1021/acs.orglett.1c01583 | Project: | MOE2019-T2-1-089 | Journal: | Organic Letters | Abstract: | A protocol for the synthesis of α-alkynylnitrones from 1,3-enynes has been developed. The process is triggered by hydromagnesiation of 1,3-enynes with magnesium hydride (MgH2), which is prepared in situ through solvothermal treatment of magnesium iodide (MgI2) with sodium hydride (NaH) in tetrahydrofuran. Downstream functionalization of the resulting propargylmagnesium intermediates with organo nitro compounds affords α-alkynylnitrones, which could be used as versatile precursors for the construction of various nitrogen-containing compounds. | URI: | https://hdl.handle.net/10356/154828 | ISSN: | 1523-7060 | DOI: | 10.1021/acs.orglett.1c01583 | Schools: | School of Physical and Mathematical Sciences | Rights: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.1c01583. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
| Appears in Collections: | SPMS Journal Articles |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Manuscript_Chiba_rev_deposit.pdf | 488.33 kB | Adobe PDF |  View/Open |
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