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https://hdl.handle.net/10356/154834
Title: | Stereo-controlled anti-hydromagnesiation of aryl alkynes by magnesium hydrides | Authors: | Wang, Bin Ong, Derek Yiren Li, Yihang Pang, Jia Hao Watanabe, Kohei Takita, Ryo Chiba, Shunsuke |
Keywords: | Science::Chemistry | Issue Date: | 2020 | Source: | Wang, B., Ong, D. Y., Li, Y., Pang, J. H., Watanabe, K., Takita, R. & Chiba, S. (2020). Stereo-controlled anti-hydromagnesiation of aryl alkynes by magnesium hydrides. Chemical Science, 11(20), 5267-5272. https://dx.doi.org/10.1039/d0sc01773f | Project: | MOE2019-T2-1-089 | Journal: | Chemical Science | Abstract: | A concise protocol for anti-hydromagnesiation of aryl alkynes was established using 1 : 1 molar combination of sodium hydride (NaH) and magnesium iodide (MgI2) without the aid of any transition metal catalysts. The resulting alkenylmagnesium intermediates could be trapped with a series of electrophiles, thus providing facile accesses to stereochemically well-defined functionalized alkenes. Mechanistic studies by experimental and theoretical approaches imply that polar hydride addition from magnesium hydride (MgH2) is responsible for the process. | URI: | https://hdl.handle.net/10356/154834 | ISSN: | 2041-6520 | DOI: | 10.1039/d0sc01773f | Schools: | School of Physical and Mathematical Sciences | Rights: | © 2020 The Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | SPMS Journal Articles |
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