Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/154834
Title: Stereo-controlled anti-hydromagnesiation of aryl alkynes by magnesium hydrides
Authors: Wang, Bin
Ong, Derek Yiren
Li, Yihang
Pang, Jia Hao
Watanabe, Kohei
Takita, Ryo
Chiba, Shunsuke
Keywords: Science::Chemistry
Issue Date: 2020
Source: Wang, B., Ong, D. Y., Li, Y., Pang, J. H., Watanabe, K., Takita, R. & Chiba, S. (2020). Stereo-controlled anti-hydromagnesiation of aryl alkynes by magnesium hydrides. Chemical Science, 11(20), 5267-5272. https://dx.doi.org/10.1039/d0sc01773f
Project: MOE2019-T2-1-089 
Journal: Chemical Science 
Abstract: A concise protocol for anti-hydromagnesiation of aryl alkynes was established using 1 : 1 molar combination of sodium hydride (NaH) and magnesium iodide (MgI2) without the aid of any transition metal catalysts. The resulting alkenylmagnesium intermediates could be trapped with a series of electrophiles, thus providing facile accesses to stereochemically well-defined functionalized alkenes. Mechanistic studies by experimental and theoretical approaches imply that polar hydride addition from magnesium hydride (MgH2) is responsible for the process.
URI: https://hdl.handle.net/10356/154834
ISSN: 2041-6520
DOI: 10.1039/d0sc01773f
Schools: School of Physical and Mathematical Sciences 
Rights: © 2020 The Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

Files in This Item:
File Description SizeFormat 
Stereo-controlled anti-hydromagnesiation of aryl alkynes by magnesium hydrides.pdf949.13 kBAdobe PDFThumbnail
View/Open

SCOPUSTM   
Citations 20

15
Updated on Mar 25, 2024

Web of ScienceTM
Citations 20

11
Updated on Oct 25, 2023

Page view(s)

117
Updated on Mar 28, 2024

Download(s) 50

47
Updated on Mar 28, 2024

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.