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Title: Controlled reduction of nitriles by sodium hydride and zinc chloride
Authors: Ong, Derek Yiren
Chiba, Shunsuke
Keywords: Science::Chemistry
Issue Date: 2020
Source: Ong, D. Y. & Chiba, S. (2020). Controlled reduction of nitriles by sodium hydride and zinc chloride. Synthesis, 52(9), 1369-1378.
Project: RG10/17
Journal: Synthesis
Abstract: A new protocol for the controlled reduction of nitriles to aldehydes was developed using a combination of sodium hydride and zinc chloride. The iminyl zinc intermediates derived from aromatic nitriles could be further functionalized with allylmetal nucleophiles to afford homoallylamines. As the method allows the reduction of various aliphatic and aromatic nitriles with a concise procedure under milder reaction conditions and exhibits wide functional group compatibility, it is well suited for use in various opportunities in chemical synthesis.
ISSN: 0039-7881
DOI: 10.1055/s-0039-1690838
Schools: School of Physical and Mathematical Sciences 
Rights: © 2020 Thieme. All rights reserved. This paper was published in Synthesis and is made available with permission of Thieme.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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