Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/154868
Title: Generation of organo-alkaline earth metal complexes from non-polar unsaturated molecules and their synthetic applications
Authors: Watanabe, Kohei
Pang, Jia Hao
Takita, Ryo
Chiba, Shunsuke
Keywords: Science::Chemistry
Issue Date: 2022
Source: Watanabe, K., Pang, J. H., Takita, R. & Chiba, S. (2022). Generation of organo-alkaline earth metal complexes from non-polar unsaturated molecules and their synthetic applications. Chemical Science, 13(1), 27-38. https://dx.doi.org/10.1039/D1SC05724C
Project: MOE2019-T2-1-089
Journal: Chemical Science
Abstract: Organomagnesium compounds, representated by the Grignard reagents, are one of the most classical yet versatile carbanion species which have widely been utilized in synthetic chemistry. These reagents are typically prepared via oxidative addition of organic halides to magnesium metals, via halogen-magnesium exchange between halo(hetero)arenes and organomagnesium reagents or via deprotonative magnesiation of prefunctionalized (hetero)arenes. On the other hands, recent studies have demonstrated that the organo-alkaline earth metal complexes including those based on heavier alkaline earth metals such as calcium, strontium and barium could be generated from readily available non-polar unsaturated molecules such as alkenes, alkynes, 1,3-enynes and arenes through unique metallation processes. Nonetheless, the resulting organo-alkaline earth metal complexes could be further functionalized with variety of electrophiles in various reaction modes. Especially, organocalcium, -strontium and barium species have shown unprecedented reactivity in the downstream functionalization, which could not be observed in the reactivity of organomagnesium complexes. This perspective will focus on the newly emerging protocols for the generation of organo-alkaline earth metal complexes from non-polar unsaturated molecules and their applications in chemical synthesis and catalysis.
URI: https://hdl.handle.net/10356/154868
ISSN: 2041-6520
DOI: 10.1039/D1SC05724C
Rights: © 2022 The Author(s). Published by the Royal Society of Chemistry. This article is licensed under a Creative Commons Attriubtion-NonCommercial 3.0 Unported License.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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