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Title: Reductive functionalization of carboxamides : a recent update
Authors: Ong, Derek Yiren
Chen, Jiahua
Chiba, Shunsuke
Keywords: Science::Chemistry
Issue Date: 2020
Source: Ong, D. Y., Chen, J. & Chiba, S. (2020). Reductive functionalization of carboxamides : a recent update. Bulletin of the Chemical Society of Japan, 93(11), 1339-1349.
Project: MOE2017-T2-1-064
Journal: Bulletin of the Chemical Society of Japan
Abstract: Carboxamides including lactams are readily available and bench-stable chemical feedstock, and thus their use in chemical synthesis for production of valuable compounds would be an attractive choice in various synthetic endeavors. This review highlights and discusses recent advances on deoxygenative reductive functionalization of carboxamides for the synthesis of -branched amines, that is initiated by controlled single hydride delivery to the amide carbonyl group and terminated by downstream functionalization of the iminium intermediates. The protocols are categorized based on the types of the reduction processes including those with aluminum hydrides, the Schwartz reagent, transition metal-catalyzed/mediated hydrosilylation, and sodium hydride-iodide composite.
ISSN: 0009-2673
DOI: 10.1246/bcsj.20200182
Schools: School of Physical and Mathematical Sciences 
Rights: © 2020 The Chemical Society of Japan. All rights reserved. This paper was published in Bulletin of the Chemical Society of Japan and is made available with permission of The Chemical Society of Japan.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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