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|Title:||Anisotropic protein diffusion on nanosurface||Authors:||Liu, Yang
|Keywords:||Science::Chemistry||Issue Date:||2020||Source:||Liu, Y., Song, X., Yang, Y., Li, Y., Zhao, M., Mu, Y. & Li, W. (2020). Anisotropic protein diffusion on nanosurface. Nanoscale, 12(8), 5209-5216. https://dx.doi.org/10.1039/c9nr08555f||Journal:||Nanoscale||Abstract:||The unique puckered structure of α-phase phosphorene carbide (α-PC) results in anisotropic electronic and thermal transporting properties. In the present work, the interactions between a model protein, villin headpiece sub-domain (HP35), and the surface of α-PC and monolayer black phosphorus (MBP, another puckered nanostructure) were explored by molecular dynamic (MD) simulations. It is found that HP35 diffuses quickly only along the zigzag direction of the α-PC surface. On the MBP surface, HP35 migrates mainly along the zigzag direction but can also easily stride over the ridges and grooves along the armchair direction. Moreover, the mild binding strength between α-PC and HP35 does not cause distortion in the protein structure. The intrinsic biocompatibility of α-PC, which is distinct from several other widely studied nanomaterials, such as carbon nanotubes, graphene and MoS2, makes it a promising candidate in functional biomedical applications.||URI:||https://hdl.handle.net/10356/154927||ISSN:||2040-3364||DOI:||10.1039/c9nr08555f||Rights:||© The Royal Society of Chemistry 2020. All rights reserved.||Fulltext Permission:||none||Fulltext Availability:||No Fulltext|
|Appears in Collections:||SBS Journal Articles|
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