Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/155058
Title: Carbene-catalyzed enantioselective hydrophosphination of α-bromoenals to prepare phosphine-containing chiral molecules
Authors: Maiti, Rakesh
Yan, Jia-Lei
Yang, Xing
Mondal, Bivas
Xu, Jun
Chai, Huifang
Jin, Zhichao
Chi, Robin Yonggui
Keywords: Science::Chemistry
Issue Date: 2021
Source: Maiti, R., Yan, J., Yang, X., Mondal, B., Xu, J., Chai, H., Jin, Z. & Chi, R. Y. (2021). Carbene-catalyzed enantioselective hydrophosphination of α-bromoenals to prepare phosphine-containing chiral molecules. Angewandte Chemie International Edition, 60(51), 26616-26621. https://dx.doi.org/10.1002/anie.202112860
Project: NRF-NRFI2016-0
NRF-CRP22-2019-0002
RG7/20
RG5/19
MOE2019-T2-2-117
MOE2018-T3-1-003
Journal: Angewandte Chemie International Edition
Abstract: Disclosed herein is the first carbene-organocatalyzed asymmetric addition of phosphine nucleophiles to the in situ generated α,β-unsaturated acyl azolium intermediates. Our reaction enantioselectively constructs carbon-phosphine bonds and prepares chiral phosphines with high optical purities. The phosphine products are suitable for transforming to chiral ligands or catalysts with applications in asymmetric catalysis. The diarylalkyl or trialkyl phosphine products from our catalytic reactions, air-sensitive and reactive in nature, can be trapped (and stored) in their sulfur-oxidized form for operational simplicities.
URI: https://hdl.handle.net/10356/155058
ISSN: 1521-3773
DOI: 10.1002/anie.202112860
Rights: This is the peer reviewed version of the following article: Maiti, R., Yan, J., Yang, X., Mondal, B., Xu, J., Chai, H., Jin, Z. & Chi, R. Y. (2021). Carbene-catalyzed enantioselective hydrophosphination of α-bromoenals to prepare phosphine-containing chiral molecules. Angewandte Chemie International Edition, 60(51), 26616-26621, which has been published in final form at https://doi.org/10.1002/anie.202112860. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Fulltext Permission: embargo_20221220
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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