Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/155061
Title: Carbene-catalyzed enantioselective annulation of dinucleophilic hydrazones and bromoenals for access to aryl-dihydropyridazinones and related drugs
Authors: Mondal, Bivas
Maiti, Rakesh
Yang, Xing
Xu, Jun
Tian, Weiyi
Yan, Jia-Lei
Li, Xiangyang
Chi, Robin Yonggui
Keywords: Science::Chemistry
Issue Date: 2021
Source: Mondal, B., Maiti, R., Yang, X., Xu, J., Tian, W., Yan, J., Li, X. & Chi, R. Y. (2021). Carbene-catalyzed enantioselective annulation of dinucleophilic hydrazones and bromoenals for access to aryl-dihydropyridazinones and related drugs. Chemical Science, 12(25), 8778-8783. https://dx.doi.org/10.1039/d1sc01891d
Project: NRF-NRFI2016-06
NRF-CRP22-2019-0002
RG108/16
RG5/19
RG1/18
MOE2019-T2-2-117
MOE2018-T3-1-003
A1783c0008
A1783c0010
Journal: Chemical Science
Abstract: 4,5-Dihydropyridazinones bearing an aryl substituent at the C6-position are important motifs in drug molecules. Herein, we developed an efficient protocol to access aryl-dihydropyridazinone molecules via carbene-catalyzed asymmetric annulation between dinucleophilic arylidene hydrazones and bromoenals. Key steps in this reaction include polarity-inversion of aryl aldehyde-derived hydrazones followed by chemo-selective reaction with enal-derived α,β-unsaturated acyl azolium intermediates. The aryl-dihydropyridazinone products accessed by our protocol can be readily transformed into drugs and bioactive molecules.
URI: https://hdl.handle.net/10356/155061
ISSN: 2041-6520
DOI: 10.1039/d1sc01891d
Schools: School of Physical and Mathematical Sciences 
Rights: © 2021 The Author(s). Published by the Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

SCOPUSTM   
Citations 20

14
Updated on Mar 25, 2024

Web of ScienceTM
Citations 20

11
Updated on Oct 27, 2023

Page view(s)

202
Updated on Mar 27, 2024

Download(s) 50

50
Updated on Mar 27, 2024

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.