Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/155070
Title: Carbene-catalyzed activation of formyl-phenylacetic esters for access to chiral dihydroisoquinolinones
Authors: Wu, Shuquan
Xu, Jun
Deng, Rui
Wang, Hongling
Chi, Robin Yonggui
Zheng, Pengcheng
Keywords: Science::Chemistry
Issue Date: 2021
Source: Wu, S., Xu, J., Deng, R., Wang, H., Chi, R. Y. & Zheng, P. (2021). Carbene-catalyzed activation of formyl-phenylacetic esters for access to chiral dihydroisoquinolinones. Organic Letters, 23(19), 7513-7517. https://dx.doi.org/10.1021/acs.orglett.1c02676
Project: NRFNRFI2016-06
NRFCRP22-2019-0002
RG7/20
RG5/19
MOE2019-T2-2-117
MOE2018-T3-1-003
Journal: Organic Letters
Abstract: A carbene-catalyzed reaction to synthesize chiral dihydroisoquinolinones via an o-quinodimethane (o-QDM) intermediate is disclosed. o-QDM reacts with cyclic sulfonic imines via annulation to afford highly enantioenriched dihydroisoquinolinone products. ESI-HRMS studies suggest a stepwise Mannich addition and acylation reaction pathway, and the pathways of the catalytic and uncatalyzed background reactions are evaluated via DFT calculations.
URI: https://hdl.handle.net/10356/155070
ISSN: 1523-7060
DOI: 10.1021/acs.orglett.1c02676
Rights: © 2021 American Chemical Society. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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